This review clarifies normal aging brain changes in an asymptotic and comprehensive manner, from a gross level to a microscopic and molecular level, and discusses potential approaches to …

Dec 1, 2021 · The present review is motivated by the development of advanced constitutive multiphysics models of age-related organ-level brain changes that relate cell- and tissue-level …

In this study, we aimed to investigate the association between brain age, which reflects global brain health, and cerebrovascular lesion load in the context of pathological aging in diverse …

May 28, 2025 · White matter hyperintensity (WMH) lesions associated with small vessel cerebrovascular disease (CVD) are common structural neuroimaging findings in older adults.

May 5, 2023 · We hypothesized that more lesion damage would result in older brain age, which would in turn be associated with poorer outcomes. Related, we expected that brain age would …

Jun 15, 2025 · Animals exposed to enriched environments exhibit higher myelin levels in the brain [33, 34, 35], and sensory enrichment increases oligodendrogenesis and oligodendrocyte …

As we age our brains shrink in volume, particularly in the frontal cortex. As our vasculature ages and our blood pressure rises the possibility of stroke and ischaemia increases and our white …

Aug 9, 2017 · To collectively assess whole-brain structural changes, the MRI-based Brain Atrophy and Lesion Index (BALI) has been developed. In this study, we validate this whole-brain health …

In this study, we evaluated measurement properties of the Brain Atrophy and Lesion Index by use of T1WI and T2WI at 1.5T and 3T MR imaging to comprehensively assess the usefulness of …

Jan 8, 2025 · Aging has a detrimental impact on white matter, resulting in reduced volume, compromised structural integrity of myelinated axons, and an increase in white matter …