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Two-input protein logic gate for computation in living cells
Nov 16, 2021 · Here, in an important step toward this goal, we report an engineered, single protein design that is allosterically regulated to function as a ‘two-input logic OR gate’. Our system is …
- Author: Yashavantha L. Vishweshwaraiah, Jiaxing Chen, Venkat R. Chirasani, Erdem D. Tabdanov, Nikolay V. Dok...
- Publish Year: 2021
See results only from nature.comSynthetic RNA-based logic c…
In this study, we construct a set of RNA-based logic circuits with RBPs that …
Designing protein logic gate…
Researchers from the group of David Baker at the University of Washington and their …
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Recent advances and opportunities in synthetic logic gates …
Two NOT gates, two AND gates, and an OR gate were connected in a network to generate XOR function (Gerasimova and Kolpashchikov 2012). A three-terminal device was developed …
Amplifying Genetic Logic Gates | Science - AAAS
Mar 28, 2013 · We realized permanent amplifying AND, NAND, OR, XOR, NOR, and XNOR gates actuated across common control signal ranges and …
- Author: Jerome Bonnet, Peter Yin, Monica E. Ortiz, Pakpoom Subsoontorn, Drew Endy
- Publish Year: 2013
Synthetic RNA-based logic computation in mammalian cells
Nov 19, 2018 · In this study, we construct a set of RNA-based logic circuits with RBPs that detect multiple miRNA inputs and regulate the output protein expression (Fig. 1a). We create five …
- Author: Satoshi Matsuura, Hiroki Ono, Shunsuke Kawasaki, Yi Kuang, Yi Kuang, Yoshihiko Fujita, Hirohide Sait...
- Publish Year: 2018
De novo design of protein logic gates | Science - AAAS
Apr 3, 2020 · The ability to de novo design protein-based logic gates modulating arbitrary protein-protein interactions could open the door to new protein-based …
- Author: Zibo Chen, Ryan D. Kibler, Andrew Hunt, Florian Busch, Jocelynn Pearl, Mengxuan Jia, Zachary L. VanA...
- Publish Year: 2020
Catalyst-based biomolecular logic gates - PMC - National Center …
Jun 29, 2023 · The NXOR gate is an XOR gate with inverted output. The NAND and NOR logic gates, while difficult to implement using biomolecules, are functionally complete operations, …
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Implementation of novel boolean logic gates for IMPLICATION …
Jan 5, 2022 · For the XOR gate, the 5ʹ end and the 3ʹ end complementary domains of trigger RNAs could combine successfully without affecting the functionality of the intermediate …
Biological Modules: Logic Gates - iGEM
The OR gate uses as input signals the product of the two AND gates. If for both gates the output gene is the same, we have an implicit OR gate: either on of the entries (or both) produce the …
Designing protein logic gates - Nature Methods
Jun 4, 2020 · Researchers from the group of David Baker at the University of Washington and their collaborators have designed proteins that can function as logic gates (AND, OR, NAND, …
Modular, Multi-Input Transcriptional Logic Gating
Jul 18, 2014 · Each gate consists of a transcription factor that requires a second chaperone protein to activate the output promoter. Multiple activator-chaperone pairs are identified from type III secretion pathways in different strains of bacteria.
Layering genetic circuits to build a single cell, bacterial half adder
Jun 16, 2015 · Design and characterisation of XOR logic gate. In order to develop the XOR component of the half adder, we assimilated and tested a combination of AND, OR and NOT …
Recent advances and opportunities in synthetic logic gates
Aug 28, 2014 · Two NOT gates, two AND gates, and an OR gate were connected in a network to generate XOR function (Gerasimova and Kolpashchikov 2012). A three-terminal device was …
De novo design of protein logic gates - PubMed
Apr 3, 2020 · The design of modular protein logic for regulating protein function at the posttranscriptional level is a challenge for synthetic biology. Here, we describe the design of …
Cellular Computational Logic Using Toehold Switches - MDPI
Mar 8, 2022 · Previously, several lines of work demonstrated RNA-based XOR gates, including sRNA , miRNA , and gRNA that encompass bacterial cells as well as mammalian cell lines. …
RNA-based XOR logic gate. a) Scheme of the gene
In this paper, utilizing the unique advantages of RNA molecules in building complex logic circuits in the cellular environment, we demonstrate the RNA-only bitwise logical operation of XOR...
Design and characterisation of biological XOR gates. a
In this paper, utilizing the unique advantages of RNA molecules in building complex logic circuits in the cellular environment, we demonstrate the RNA-only bitwise logical operation of XOR...
A Biological OR(XNOR) Logic Gate Couples Carbon Source and …
Feb 27, 2023 · We constructed a three-input biological logic gate: S OR (G XNOR M), where S is sorbitol, G is glycerol, and M is methanol, to optimize co-expression of two transgenes in …
A biological XOR gate with three genes and 2 complex reactions.
The XOR gate is made of a set of three genes (Fig. 3). The first one leads to the synthesis of a protein ZFA1, and an inhibitor of the protein ZFA2, when the protein A is present in the cell....
Analysis of functional genomic signals using the XOR gate
Using the exclusive-OR (XOR) logic gate, we formulated a scheme to threshold signals that may correlate to putative active transcriptional modules from a population of random genomic …
DNA-based XOR logic gate design and XOR truth table. A)
In response to the NIST's "International Call for Hash Function", we developed a biological hash function using the computing capabilities of bacteria. We designed a DNA-based XOR logic …
Transport and InsP8 gating mechanisms of the human inorganic …
Mar 20, 2025 · The residues are clustered near protein regions critical for function, including (1) the substrate translocation pathway, (2) the Arg extension and capture pocket, and (3) the …
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