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Efficacy of Amphotericin B in Combination with Flucytosine …
For the flucytosine-resistant isolate, the combination of amphotericin B at 0.5 mg/kg/day with flucytosine at 100 mg/kg/day was significantly better than monotherapies for reducing the …
- Amphotericin B and Flucona…
  This study demonstrates that amphotericin B plus fluconazole is better than …
- Use of Antifungal Combinati…
  This open-label phase 2 trial compared the combination of amphotericin B and …
- Comparison of liposomal am…
  Objectives: In the present study, we compared the efficacy of liposomal …
- Pharmacodynamics of Lipos…
  Both LAmB and flucytosine produced a dose-dependent reduction in fungal …
- High-dose amphotericin B w…
  Background: The standard therapy for human immunodeficiency virus (HIV) …
- Pharmacokinetics of amphot…
  Fungistatic levels are achieved rapidly with flucytosine and slowly with amphotericin …
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The New England Journal of Medicine
https://www.nejm.org › doi › full
Combination Antifungal Therapy for …
Apr 4, 2013 · Combination antifungal therapy (amphotericin B deoxycholate and flucytosine) is the recommended treatment …
Author: Jeremy N. Day, Tran T.H. Chau, Marcel Wolbers, Pham P. Mai, Nguyen T. Dung, Nguyen H. Mai, Nguyen H....
Publish Year: 2013
hopkinsguides.com
https://www.hopkinsguides.com › ... › all › Flucytosine
Flucytosine | Johns Hopkins ABX Guide - Hopkins Guides
May 1, 2017 · Recommended in combination with amphotericin or liposomal amphotericin for treatment of cryptococcal meningitis for at least 2 weeks. Combination therapy with flucytosine …
Studies of amphotericin b and flucytosine
PubMed
Comparison of liposomal amphotericin B alone and in combination with flucytosine in the treatment of non-HIV Cryptococcal meningitis: A nationwide observational study
Background: Cryptococcal meningitis (CM) is an opportunistic infectious disease that occurs in immunocompromised hosts, not only in patients living with HIV, but also in patients without HIV. The evidence regarding the treatment for CM in patients without HIV is mainly found in small retrospective s...
Author: Takahiro Taka…
Published: 2022/9
Keywords: Cryptococc…
PubMed
High-dose amphotericin B with flucytosine for the treatment of cryptococcal meningitis in HIV-infected patients: a randomized trial
Background: The standard therapy for human immunodeficiency virus (HIV)-associated cryptococcal meningitis of amphotericin B (AmB; 0.7 mg/kg per day) plus flucytosine frequently takes >2 weeks to sterilize the cerebral spinal fluid, and acute mortality remains high. A dosage range for AmB of 0.7-1 m...
Author: Tihana Bicanic
Published: 2008/07/01
Keywords: The standa…
National Center for Biotechnology Information
Pharmacodynamics of Liposomal Amphotericin B and Flucytosine for Cryptococcal Meningoencephalitis: Safe and Effective Regimens for Immunocompromised Patients
Background. Cryptococcal meningoencephalitis is a lethal infection with relatively few therapeutic options. The optimal dosage of liposomal amphotericin B (LAmB) alone or in combination with flucytosine is not known. Methods. A murine model of cryptococcal meningoencephalitis was used. The fungal...
Author: Lucy O'Connor…
Published: 2013/07/07
Publication: J Infect Di…
ScienceDirect
Mycology Evaluation of amphotericin B and flucytosine in combination against Candida albicans and Cryptococcus neoformans using time-kill methodology
In this study, time-kill methods were used to evaluate the antifungal activity of amphotericin B and flucytosine, alone and in combination, against six isolates of Candida albicans and Cryptococcus neoformans. Five regimens were tested against each isolate: (1) flucytosine, (2) low-dose amphotericin...
Published: 2001/11/01
Cited By: 0
Keywords: Antifungals…
National Center for Biotechnology Information
Pharmacokinetics of amphotericin B and flucytosine.
The absorption of flucytosine from the digestive tract is very good but minimal with amphotericin B. For this reason, amphotericin B has to be injected intravenously. Fungistatic levels are achieved rapidly with flucytosine and slowly with amphotericin B, since the dose has to be increased slowly. D...
Author: A. Polak
Published: 1979/09
Publication: Postgrad …
ResearchGate
Comparison of Amphotericin B and its Combination with Flucytosine in the Management of Cryptococcal Meningitis: A Review
Cryptococcosis is a global invasive mycosis that is associated with high morbidity and mortality. With its profound propensity to locate within the central nervous system, which is frequently accompanying by fungal meningitis. Immunocompromised patients with cryptococcal meningitis should receive Am...
Published: 2021/03/27
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Amphotericin B and Fluconazole, a Potent Combination Therapy …
This study demonstrates that amphotericin B plus fluconazole is better than amphotericin B plus flucytosine and that the addition of flucytosine does not improve the antifungal effect of …

Cleveland Clinic Journal of Medicine
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Vulvovaginitis: Find the cause to treat it
Mar 1, 2017 · Amphotericin B 50 mg vaginal suppositories for 14 days. Boric acid is readily available, but flucytosine vaginal …
Author: Oluwatosin Goje, Jessian L. Munoz
Estimated Reading Time: 9 mins
Publish Year: 2017
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Use of Antifungal Combination Therapy: Agents, Order, and Timing
This open-label phase 2 trial compared the combination of amphotericin B and fluconazole (at high or low dosages) versus amphotericin B alone as induction therapy for HIV-associated …
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Can flucytosine be combined with amphotericin & fluconazole?
Combination therapy with flucytosine results in more rapid CSF sterilization and improved mortality when compared to amphotericin alone. When compared to amphotericin plus fluconazole, there was no difference in survival outcomes but combination with flucytosine resulted in more rapid CSF sterilization.
Flucytosine | Johns Hopkins ABX Guide - Hopkins Guides
hopkinsguides.com
Can flucytosine be used with amphotericin B?
However, the recommended use is in conjunction with another antifungal medication. The standard flucytosine use sequence is combined with amphotericin B, which serves a synergistic effect when used together for systemic infections.
Flucytosine - StatPearls - NCBI Bookshelf
ncbi.nlm.nih.gov
Is amphotericin B more effective than fluconazole?
Therefore, we tested two new treatment strategies that could be more readily sustainable in African centers than 2 weeks of amphotericin B and more effective than fluconazole: oral therapy with higher-dose fluconazole plus flucytosine, and a shorter course (1 week) of induction therapy with amphotericin B–based treatment.
Antifungal Combinations for Treatment of Cryptococcal Meningitis in
nejm.org
Does amphotericin B & fluconazole sterilize cerebrospinal fluid?
In a small study, the combination of amphotericin B plus fluconazole did not sterilize cerebrospinal fluid (CSF) better than amphotericin B alone or a triple combination of amphotericin B, fluconazole, and flucytosine. Amphotericin B plus flucytosine resulted in sterilization of the CSF faster than any of the other treatments .
Use of Antifungal Combination Therapy: Agents, Order, and Timing
pmc.ncbi.nlm.nih.gov
Does amphotericin B deoxycholate plus flucytosine 5 have a standard induction treatment?
The international standard induction treatment of 2 weeks of amphotericin B deoxycholate plus flucytosine 5 is not available in most African clinical centers.
Antifungal Combinations for Treatment of Cryptococcal Meningitis in
nejm.org
Can amphotericin B plus fluconazole treat cryptococcal meningitis?
In addition, the combination of amphotericin B plus fluconazole does not have significant advantages over the standard of amphotericin B plus flucytosine for cryptococcal meningitis, but it could be an alternative regimen for resource-limited settings.
Use of Antifungal Combination Therapy: Agents, Order, and Timing
pmc.ncbi.nlm.nih.gov
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The New England Journal of Medicine
https://www.nejm.org › doi › full
Antifungal Combinations for Treatment of …
Mar 14, 2018 · We tested two treatment strategies that could be more sustainable in Africa than the standard of 2 weeks of amphotericin B plus flucytosine and more effective than the …
PubMed
https://pubmed.ncbi.nlm.nih.gov
Comparison of liposomal amphotericin B alone and in …
Objectives: In the present study, we compared the efficacy of liposomal amphotericin B (L-AMB) alone and in combination with flucytosine (5-FC) for the induction treatment of CM in patients …
PubMed
https://pubmed.ncbi.nlm.nih.gov
High-dose amphotericin B with flucytosine for the treatment of
Jul 1, 2008 · Background: The standard therapy for human immunodeficiency virus (HIV)-associated cryptococcal meningitis of amphotericin B (AmB; 0.7 mg/kg per day) plus …
Mayo Clinic Proceedings
https://www.mayoclinicproceedings.org › article › fulltext
Antifungal Agents. Part I. Amphotericin B Preparations …
Any nephrotoxic agent that reduces creatinine clearance will increase the serum concentration of flucytosine. Amphotericin B deoxycholate will predictably have such an effect in a dose-related fashion; higher doses will cause more renal …
National Center for Biotechnology Information
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Flucytosine - StatPearls - NCBI Bookshelf - National Center for ...
Feb 28, 2024 · The standard flucytosine use sequence is combined with amphotericin B, which serves a synergistic effect when used together for systemic infections. This combination …
National Center for Biotechnology Information
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Pharmacodynamics of Liposomal Amphotericin B and Flucytosine …
Jul 7, 2013 · Both LAmB and flucytosine produced a dose-dependent reduction in fungal burden. The effect of the combination of agents in the brain was additive. Bridging studies suggested …
plos.org
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Major Role for Amphotericin B–Flucytosine Combination in
Aug 6, 2008 · Treatment failure (death or mycological failure) at Wk2 and Mo3 was the main outcome measured. Combination of amphotericin B+flucytosine (AMB+5FC) was the best …
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Combination of Amphotericin B with Flucytosine Is Active In Vitro ...
In vitro interaction of flucytosine combined with amphotericin B or fluconazole against thirty-five yeast isolates determined by both the fractional inhibitory concentration index and the …
The New England Journal of Medicine
https://www.nejm.org › doi › full
A Comparison of Amphotericin B Alone and Combined with …
Flucytosine plus amphotericin B was superior to amphotericin B alone. The ability to achieve a favorable therapeutic result in only six weeks is important, in view of the costs of...
ScienceDirect
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Evaluation of amphotericin B and flucytosine in combination …
Nov 1, 2001 · In this study, time-kill methods were used to evaluate the antifungal activity of amphotericin B and flucytosine, alone and in combination, against six isolates of Candida …
Oxford Academic
https://academic.oup.com › cid › article
High-Dose Amphotericin B with Flucytosine for the Treatment of ...
Jul 1, 2008 · The standard therapy for human immunodeficiency virus (HIV)–associated cryptococcal meningitis of amphotericin B (AmB; 0.7 mg/kg per day) plus flucytosine frequently …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
Pharmacokinetics of amphotericin B and flucytosine. - PMC
Fungistatic levels are achieved rapidly with flucytosine and slowly with amphotericin B, since the dose has to be increased slowly. Distribution of flucytosine in other body fluids is high, …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Flucytosine and Amphotericin B Coadministration Induces Dose …
In this study, we aimed to evaluate the nephrotoxicity induced by combined therapy of flucytosine (FL) and amphotericin B (AMF) at 3 different doses administered to mice for 14 days: 300 …
ResearchGate
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Comparison of Amphotericin B and its Combination with …
Mar 27, 2021 · Immunocompromised patients with cryptococcal meningitis should receive Amphotericin B deoxycholate 0.7–1.0 mg/kg/day intravenously plus Flucytosine 100 mg/kg/day …
ASM Journals
https://journals.asm.org › doi
Rapid in vitro evolution of flucytosine resistance in Candida auris
6 days ago · Clinical resistance to azoles and amphotericin B (AMB) is alarmingly high, as they reach ~90% and up ... Jean D, Chastin C, Villard J, Chapeland-Leclerc F. 2007. Molecular …
BMC Biology
https://bmcbiol.biomedcentral.com › articles
Gfa1 (glutamine fructose-6-phosphate aminotransferase) is …
Mar 13, 2025 · B After 7 days, conidia were harvested and counted using a hemocytometer. Asterisk indicate a significant difference (multiple t test, ****, ... amphotericin B (AmB), …
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