Of course CSS grid and flexbox can work together in a layout. You can use flexbox inside CSS grid and vice versa. For instance, you could use flexbox to center an element like a button both vertically and horizontally within a particular grid cell (since centering with other CSS methods is … tricky).

When used together, Flexbox can be used to control the layout of individual items within a Grid container. For example, you could use Flexbox to center align items within a Grid cell, or to reorder items based on screen size.