UAB is located on the Southside neighborhood of downtown Birmingham, Alabama, occupying more than 100 city blocks and surrounded by three historic district neighborhood including the Five Point South, Glen Iris, and the Southside. There is a blend of public and private property inside the university limits. I-65, 10th, 11th, and 12th Avenues South, 22nd Street South, and 2nd Avenue South are the boundaries of UAB campus. The campus has more than 216 academic, residential, and recreational facilities spread across around 636 acres, or roughly 16 million square feet of building area.

The UAB strategic plan's pillars are supported by the campus master plan, which places an emphasis on innovative facilities and improved growth management. The campus master plan also includes the creation of eight zones concentration locations: Academics, Athletics & Recreation, Cultural, Hospital/Highlands, Residential, Research, Southern Research, and Support with overlapping zone areas of collaboration such as Academic, Research, and Hospital. Honors Hall, the Collat School of Business, the School of Nursing, University Hall, Gold Hall, McMahon Hall, McCallum Basic Health Science Building, Early Learning Center, and the Technology Innovation Center are amongst the recently completed building construction projects on the university. The Science and Engineering Complex's second phase project, the Altec/Styslinger Genomic Medicine & Data Sciences Building, the Marnix E. Heersink Institute for Biomedical Innovation Conference Center, Biomedical Research and Psychology Building, Unity Park, Department of Art and Art History, Cooper Green Mercy Health, University Emergency Department, Rehabilitation Pavilion, 14th Street Parking Deck, and the Southern Research Biotechnology Building are among the ongoing constructions in the university. Since 2013, about 1.1 million gross square feet of new facilities have been added to UAB's footprint through the completion or ongoing development of 17 major university construction projects.
UAB's Campus Green, also referred to as "the Green", is an open green area and a quadrangle intended for usage by members of the university community and visitors. It was built in 2008 and considered to be the focal point of the campus. The university's long-term master plan, which describes Campus Green as "the signature open space and the center of the academic core," includes the quadrangle as a key element. The Green is surrounded by green grasses, plants, shrubs, trees and walkways, that include 10th Avenue South, University Boulevard, the Chemistry Building, University Dining Facility, Camp Hall, Blazer Hall, Heritage Hall, University Hall (UAB College of Arts & Sciences) and the Campus Recreation Center. The Green is a part of a centuries-old higher education tradition that offers a serene outdoor space for introspective t…

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UAB is governed by the Board of Trustees of the University of Alabama System. The board is self-nominating and composed of 15 elected members and two ex officio members. Board members are confirmed by the Alabama State Senate.

The president of the University of Alabama at Birmingham and is appointed by the chancellor. The president also chairs the board of the UAB Health System. Richard Marchase was named interim president on August 21, 2012, after the retirement of Carol Garrison. In February 2013, Ray L. Watts became UAB's seventh president.
UAB is composed of one college, nine schools, an honors college and a graduate school. These academic divisions offer 57 bachelor's degree programs, 69 master's degree programs,3 specialist's, 42 doctoral programs, and 3 professional degrees.

Colleges and schools are:
• College of Arts and Sciences (2010)
• Collat School of Business (1971)
• School of Dentistry (UAB; 1948): founded as the only dental school in Alabama. The School of Dentistry admitted its first class of students in October 1948. The development of "four-handed dentistry" and the expanded utilization of trained auxiliary personnel were pioneered at this institution. From 2012 through 2015 the School was ranked first in research funding from the National Institute of Dental and Craniofacial Research.
• School of Education and Human Sciences (1971)
• School of Engineering (1971)
• Graduate School (1969)
• School of Health Professions (1969)
• Heersink School of Medicine (1944): the School of Medicine moved to Birmingham in 1948 from the university campus in Tuscaloosa and became a four-year school.
• Honors College (2011)
• School of Nursing (1950)
• School of Optometry (1969)
• School of Public Health (1981)
UAB's endowment reached more than 1 billion dollars after a 2018 campaign goal. It includes more than 103,000 donors, which is the largest fundraising campaign effort in UAB history.
UAB received more than $715 million in research grants and extramural awards for FY 2022.

UAB is a large, four-year research university and is classified among "R1: Doctoral Universities – Very high research activity". UAB has been accredited by the Southern Association of Colleges and Schools since 1970, according to the U.S. Department of Education. UAB offers degrees in the undergraduate, graduate, and doctoral levels from the schools in Business, Education, Engineering, Graduate School, Health Professions, Nursing, Public Health, and the College of Arts and Sciences. It also houses the Honors College and the three professional schools that offer professional degrees in dentistry, Medicine, and Optometry. UAB has inaugurated some new programs in bioinformatics, cancer biology genetics and genomic sciences, digital forensic immunology and neuro-engineering that are the first of its kind in the US.
With almost 2 million clinical visits and care provided every year, UAB is considered one of the largest academic medical centers that offers patient care to the state of Alabama and the surrounding areas. The institution is also training future medical professionals and advancing medical science through study and research at health-related professional schools of UAB; Dentistry, Health Professions, Nursing, Optometry, Public Health and the Heersink School of Medicine. A number of managed hospitals are part of the UAB Health System, including the UAB Hospital, the Valley Foundation, the University of Alabama Health Services Foundation, the UAB Carolan Eye Hospital Authority, the Medical West Hospital Authority, the L.V. Stabler Hospital, J. Paul Jones Hospital, Brian Whitfield Memorial Hospital, Cooper Green Mercy Health Services Authority, and other local hospitals. Ascension St. Vincent's and UAB Health System have formed a collaborative partnership to expand access to healthcare through numerous locations and wellness initiatives. Diabetes, mental and behavioral health, and health disparities are addressed by this partnership. Additionally, it maintains close relationships with other public and private nonprofit organizations that are housed on and around the UAB campus, such as the Children's of Alabama and the Veterans Affairs Medical Center. The UAB Health System, a distinct not-for-profit organization, oversees, coordinates, and manages the medical facilities connected to UAB.

With 1,207 beds, the flagship UAB Hospital is the largest in Alabama and the eighth largest in the nation. It is home to the only Level 1 adult trauma center in the state and the only hospital in Alabama to consistently rank among U.S. News & World Report's "America's Best Hospitals". The O'Neal Comprehensive Cancer Center is the only center in Alabama and the surrounding four states to get an NCI designation, and it leads the country in advancing cancer research, care, and education.

Providing a peer-reviewed proof of concept for xenotransplantation and paving the way for a steady, sustainable supply of life-saving organs, UAB successfully tested the first human preclinical model for transplanting genetically modified pig kidneys into humans in January 2022.
In the 2022 U.S. News & World Report rankings, UAB was tied for the 137th best national university and was ranked tied for the 64th best public university.

UAB graduate programs was ranked in the 2024 U.S. News & World Report "Best Graduate Schools" including Healthcare Management (1st), Nursing; Masters (10th) and Doctoral (11th), Nursing-Anesthesia (29th), Medical Schoo…

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