StructureCurrently, only the structure of type IVA secretion systems, which occur in gram-negative bacteria, is well described. It is composed of 12 protein subunits, VirB1 - VirB11 and VirD4, analogies of which exist in all type I… See more
MechanismDue to the wide variety of type IV secretion systems in both origin and function, it is difficult to state much mechanistically about the group as a whole.
In general, after DNA is packaged in a conjugativ… See more
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Type IV secretion systems: Advances in structure, function, and ...
Bacterial type IV secretion systems (T4SSs) are a functionally diverse translocation superfamily. They consist mainly of two large subfamilies: (i) conjugation systems that mediate …
- Author: Tiago R D Costa, Laith Harb, Pratick Khara, Lanying Zeng, Bo Hu, Peter J Christie
- Publish Year: 2021
Mechanism and structure of the bacterial type IV secretion systems
Aug 1, 2014 · The bacterial type IV secretion systems (T4SSs) translocate DNA and protein substrates to bacterial or eukaryotic target cells generally by a mechanism dependent on …
Molecular architecture of bacterial type IV secretion systems
Bacterial type IV secretion systems (T4SSs) are a versatile group of nanomachines that can horizontally transfer DNA through conjugation and deliver effector proteins into a wide range of …
Bacterial Secretion Systems – An overview - PMC
The Type IV Secretion System. Type IV secretion systems (T4SSs) are ancestrally related to bacterial DNA conjugation systems and can secrete a variety of substrates, including single …
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Structural and functional diversity of type IV secretion systems
Oct 9, 2023 · Sgro, G. G. et al. Cryo-EM structure of the bacteria-killing type IV secretion system core complex from Xanthomonas citri. Nat. Microbiol. 3, 1429–1440 (2018).
Biogenesis, Architecture, and Function of Bacterial Type IV …
Type IV secretion (T4S) systems are ancestrally related to bacterial conjugation machines. These systems assemble as a translocation channel, and often also as a surface filament or protein …
BIOLOGICAL AND STRUCTURAL DIVERSITY OF TYPE IV …
The bacterial type IV secretion systems (T4SSs) are a functionally diverse superfamily of secretion systems found in many species of bacteria. Collectively, the T4SSs translocate DNA …
THE VERSATILE BACTERIAL TYPE IV SECRETION SYSTEMS
Bacteria use type IV secretion systems for two fundamental objectives related to pathogenesis — genetic exchange and the delivery of effector molecules to eukaryotic target cells.
The structural biology of type IV secretion systems - Nature
Type IV secretion systems (T4SSs) are versatile secretion systems that are found in both Gram-negative and Gram-positive bacteria and secrete a wide range of substrates, from single …
The versatile bacterial type IV secretion systems - Nature
Nov 1, 2003 · Bacteria use type IV secretion systems for two fundamental objectives related to pathogenesis — genetic exchange and the delivery of effector molecules to eukaryotic target cells.
Type IV secretion in Gram-negative and Gram-positive bacteria
Type IV secretion systems (T4SSs) are versatile multiprotein nanomachines spanning the entire cell envelope in Gram-negative and Gram-positive bacteria. They play important roles through …
Type IV Secretion System - an overview | ScienceDirect Topics
Type IV secretion systems are nanomachines that transport substrates through bacterial membranes. Structures of components obtained by crystallography are presented. Higher …
THE VERSATILE BACTERIAL TYPE IV SECRETION SYSTEMS …
Bacteria use type IV secretion systems for two fundamental objectives related to pathogenesis — genetic exchange and the delivery of effector molecules to eukaryotic target cells.
Type IV secretion systems: tools of bacterial horizontal gene …
Type IV secretion systems (T4SSs) are multisubunit cell-envelope-spanning structures, ancestrally related to bacterial conjugation machines, which transfer proteins and …
Structural and functional diversity of type IV secretion systems
In this Review, we aim to summarize these exciting structural and molecular biology findings and to discuss their functional implications for substrate recognition, recruitment and translocation, …
Molecular architecture of bacterial type IV secretion systems
Aug 11, 2022 · Bacterial type IV secretion systems (T4SSs) are a versatile group of nanomachines that can horizontally transfer DNA through conjugation and deliver effector …
Type IV Secretion System - an overview | ScienceDirect Topics
Type IV secretion systems translocate bacterial macromolecules into the extracellular compartment or into other cells. The translocated molecules range from proteins that are …
Biological Diversity and Evolution of Type IV Secretion Systems
The bacterial type IV secretion systems (T4SSs) are a highly functionally and structurally diverse superfamily of secretion systems found in many species of Gram-negative and -positive …
Unveiling the endogenous CRISPR-Cas system in
3 days ago · This system comprises two CRISPR arrays and noteworthy DinG and Cas3 proteins, supporting recent evidence about the association between type IV and I CRISPR systems. …
Bacterial Type IV Secretion Systems: Versatile Virulence Machines
Type IV secretion systems (T4SSs) are specialized macromolecule delivery machines ancestrally related to bacterial conjugation systems.
23.4: Type IV Hypersensitivities - Biology LibreTexts
3 days ago · Accumulation of immune complexes in tissue leads to tissue damage mediated by other immune system effectors. Type IV hypersensitivity reactions are T-cell–mediated …
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