The nickel defense ’s main weakness lies in defending the run game. Even though it includes four down linemen, the lack of a third (or sometimes second) linebacker can be problematic when defending against the run.

A potential disadvantage to using a nickel defense is an increased risk of a running play on the nickel backside. A nickel back's strength is providing good cover on a fast player. Nickel backs are not usually the best at stopping the run.

One major disadvantage is its vulnerability against power-running plays. With only five defensive linemen, the Nickel Defense can struggle to stop strong running backs who can break through the line of scrimmage and gain significant yardage. This weakness can be exploited by opponents who have a strong running game.