• Adam Sandler as:
• Katie Holmes as Erin Sadelstein, Jack's wife and Jill's sister-in-law
• Al Pacino as himself, an actor who Jack is instructed to get for a Dunkin' Donuts commercial
• Eugenio Derbez as:
• Tim Meadows as Ted
• Santiago Segura as Eduardo
• Nick Swardson as Todd
• Allen Covert as Otto, a homeless man who attends Jack's Thanksgiving dinner. Covert played a similar role in Happy Gilmore, in which he is also a caddy for the titular character.
• Rohan Chand as Gary Sadelstein, Jack and Erin's adoptive son and Jill's nephew
• Elodie Tougne as Sofia Sadelstein, Jack and Erin's biological daughter and Jill's niece
• Geoff Pierson as Carter Simmons, Erin's father
• Valerie Mahaffey as Bitsy Simmons, Erin's mother
• Gad Elmaleh as Xavier
• Gary Valentine as Dallas
• Kristin Davis as Delilah
• Norm Macdonald as "Funbucket", Jill's blind date
• Julia Perri as Sally Cashier
• Dana Carvey as a Scrapply Puppeteer
• David Spade as Monica
• Jackie Seiden as Tracy
• Georgia Hatzis as Carol
The film features cameos from Johnny Depp, Regis Philbin (in his final film appearance), Dan Patrick, Shaquille O'Neal, Drew Carey, John McEnroe, Christie Brinkley, Bill Romanowski, Michael Irvin, Jared Fogle, Billy Blanks, Vince Offer, Günter Schlierkamp and Caitlyn Jenner (the latter prior to her transition, as Bruce Jenner) as themselves.

In 2024, Al Pacino elaborated on his decision to join the cast of the film, stating, "It came at a time in my life that I needed it, because it was after I found out I had no more money. My accountant was in prison, and I needed something quickly. So I took [Jack and Jill]."

The film opened in 3,438 theaters at #2 with $25,003,575, behind Immortals, which debuted in the top spot with $32,206,425. The film closed on February 26, 2012, with a total gross of $74,158,157 in North America. It also made $75,515,631 in other territories, for a total worldwide gross of $149,673,788 against its $79 million budget.
Unusually, Jack and Jill was screened for critics in Ireland but not in the United Kingdom. It was panned by reviewers.

On Rotten Tomatoes, the film has an approval rating of 3% based on 116 reviews, with an average rating of 2.90/10. The website's critical consensus reads, "Although it features an inexplicably committed performance from Al Pacino, Jack and Jill is impossible to recommend on any level whatsoever." On Metacritic, the film has a weighted average score of 23 out of 100, based on 26 critics, indicating "generally unfavorable" reviews. Audiences polled by CinemaScore gave the film an average grade of "B" on a scale of A+ to F.

On the day of the premiere, comedians such as Jake Fogelnest launched a parody promotional account on Twitter bashing the film; garnering hundreds of followers and its posts retweeted by figures such as Aziz Ansari, Paul Scheer and Alan Sepinwall. It was taken down by Twitter that evening due to a complaint from a Sony executive.

Critics from The Daily Beast, The Austin Chronicle and Time declared Jack and Jill to be the worst Sandler film. Critique that were noted issues in other Sandler films were present, and even worsened, in Jack and Jill. Common criticisms were targeted toward the crude humor, product placement, celebrity cameos, and a sentimental ending that contradicts the film's mostly mean-spirited tone.

The A.V. Club's Scott Tobias critiqued Sandler's lack of passion, describing most scenes with the actor "waiting around for somebody to feed him a line". Time contributor Mary Pols described a joke about Jack's obsessed fear of anti-semitism as a punch line with no joke.

Peter Travers of Rolling Stone also argued, "Al Pacino said something great. After he looks at himself in the commercial, he says, 'Burn this! Nobody must ever see this!' That's my review of Jack and Jill."

Andrew Barker of Variety said that the film's "general stupidity, careless direction and reliance on a single-joke premise that was never really funny to begin with are only the most obvious of its problems".

Pacino's …

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