Histamine - Wikipedia
Histamine is an organic nitrogenous compound involved in local immune responses communication, as well as regulating physiological functions in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus.
Synthesis and metabolismHistamine is derived from the decarboxylation of the amino acid histidine, a reaction catalyzed by the enzyme L-histidine decarboxylase. It is a hydrophilic vasoactive amine.
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Biochemistry, Histamine - StatPearls - NCBI Bookshelf
May 1, 2023 · Histamine is a biogenic amine synthesized from L-histidine exclusively by L-histidine decarboxylase, which uses pyridoxal-5’-phosphate …
- Published: 2023/05/01
Structural basis of ligand recognition and activation of the …
Sep 27, 2024 · Inside the ligand pocket, we identify key motifs for the recognition of histamine, the distinct binding orientations of histamine and three subpockets that facilitate the design of …
Histamine | C5H9N3 | CID 774 - PubChem
Histamine is a member of the class of imidazoles that is 1H-imidazole substituted at position C-4 by a 2-aminoethyl group. It has a role as a human metabolite, a mouse metabolite and a neurotransmitter. It is an aralkylamino compound and …
Histamine | Description & Facts | Britannica
Oct 17, 2024 · Histamine is chemically classified as an amine, an organic molecule based on the structure of ammonia (NH 3). It is formed by the decarboxylation (the removal of a carboxyl group) of the amino acid histidine.
Histamine: A Messenger Molecule Within and Outside …
The chemical structure of histamine has similarities to the structure of other biogenic amines, but important differences also exist. Chemically, histamine is 2- (4-imidazolyl)ethylamine (Fig. 14-1). The ethylamine “backbone” is a common …
Dynamics of Histamine in the Brain - Basic …
Histamine synthesis in the brain is controlled by the availability of l-histidine and the activity of histidine decarboxylase. Figure 14-4 depicts the dynamics of histamine in mammalian brain. Although histamine is present in plasma, it …
Histamine - an overview | ScienceDirect Topics
Histamine, formed from the amino acid histidine (Fig. 18-1), is a ubiquitous amine that modulates local immune responses and regulates physiologic function including gastric secretion, …
Histamine is synthesized from the L‐histidine amino acid in both the neuronal cell bodies and axon terminals and stored in vesicles in axon varicosities. In the brain, histamine is also...
Histamine Mechanism - News-Medical.net
Jul 14, 2023 · Histamine is classified as an amine because it is based on the structure of ammonia and is formed through decarboxylation of the amino acid histidine. Histamine is an …
The basics of histamine biology - PubMed
Study selection: Key articles were selected that, taken together, provide a history of scientific insight into histamine biology and receptors and mechanism of action of antihistamines. …
Histamine: Insights into Structure, Synthesis, Metabolism and the ...
Apr 10, 2022 · Histamine is synthesized from the Lhistidine amino acid in both the neuronal cell bodies and axon terminals and stored in vesicles in axon varicosities. In the brain, histamine is …
Histamine - SpringerLink
Jan 1, 2015 · Multiple biological activities of histamine are mediated by four plasma membrane histamine receptors H 1 –H 4, members of the superfamily of G-protein-coupled receptors …
Molecular Sites of Histamine Action - Basic …
Long before the receptor structure was known, histamine was postulated to activate the H 2 receptor by a three-site mechanism consisting of neutralization of the side chain ethylammonium, with proton donation and proton acceptance …
Histamine - an overview | ScienceDirect Topics
Histamine is synthesized by the neuroendocrine system cells, and secreted by immune system cells, both at the systemic and local level; its functions are regulated through its interaction …
Cryo-EM structure of the human histamine H1 receptor/Gq …
Apr 7, 2021 · Here, the authors present the cryo-EM structure of histamine-bound H1R/Gq complex and propose a mechanism of ligand induced receptor activation.
Histamine - an overview | ScienceDirect Topics
Introduction. Histamine is a low-molecular weight amine synthesized from l -histidine by histidine decarboxylase, an enzyme expressed throughout the body, including mast cells, gastric …
(PDF) Histamine - ResearchGate
Nov 19, 2020 · The structure and metabolism of histamine is discussed, together with the various types of histamine receptors. Histamine plays a role in anaphylaxis, mast cell activation …
Histamine - American Chemical Society
Apr 16, 2018 · Histamine is an organic triamine that is a strong vasodilator found in blood and most bodily tissues. It is involved in inflammatory and immune responses. Histamine is stored …
Histamine - an overview | ScienceDirect Topics
Histamine is a biogenic amine with extensive effects on many immune cell types. Histamine and its four receptors (H1R–H4R) represent a complex system of immunoregulation with distinct …
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