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  1. Astrocyte reactivity influences amyloid-β effects on tau ... - Nature

    May 29, 2023 · In vitro evidence suggests that reactive astrocytes unleash Aβ effects in pathological tau phosphorylation. Here, in a …

  2. Targeting amyloid-β pathology by chimeric antigen receptor astrocyte ...

    Mar 5, 2026 · Here, we introduce anti-amyloid chimeric antigen receptors expressed in astrocytes (CAR-A) and validate their function …

  3. Amyloid-β clearance: an astrocytic perspective - Frontiers

    May 7, 2026 · Simvastatin and atorvastatin facilitates amyloid β-protein degradation in extracellular spaces by increasing neprilysin …

  4. Astrocyte biomarker signatures of amyloid-β and tau pathologies in ...

    Aug 10, 2022 · Astrocytes can adopt multiple molecular phenotypes in the brain of Alzheimer’s disease (AD) patients. Here, we …

  5. Amyloid-β accumulation in human astrocytes induces ... - Springer

    Feb 20, 2023 · Astrocytes play a central role in maintaining brain energy metabolism, but are also tightly connected to the …

  6. The role of astrocytes in amyloid production and Alzheimer's disease

    Dec 13, 2017 · It was thought that neuronal cells were the major source of Aβ. However, mounting evidence suggests that astrocytes …

  7. Amyloid-β deposits in human astrocytes contain truncated and highly ...

    Mar 1, 2024 · Using a battery of experimental techniques, including mass spectrometry, western blot, ELISA and electron microscopy …

  8. Astrocytes clear amyloid plaques and preserve cognitive function in ...

    Nov 21, 2025 · The mechanism involves recruiting brain cells known as astrocytes, star-shaped cells in the brain, to remove the toxic …

  9. Unravelling the spatiotemporal dynamics of amyloid-

    Apr 29, 2026 · These findings demonstrate how astrocyte–neuron crosstalk and diffusion-driven instabilities contribute to emergent …

  10. Amyloid-β accumulation in human astrocytes induces mitochondrial ...

    Astrocytes play a central role in maintaining brain energy metabolism, but are also tightly connected to the pathogenesis of …