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Astrocyte reactivity influences amyloid-β effects on tau ... - Nature
May 29, 2023 · In vitro evidence suggests that reactive astrocytes unleash Aβ effects in pathological tau phosphorylation. Here, in a …
Targeting amyloid-β pathology by chimeric antigen receptor astrocyte ...
Mar 5, 2026 · Here, we introduce anti-amyloid chimeric antigen receptors expressed in astrocytes (CAR-A) and validate their function …
Amyloid-β clearance: an astrocytic perspective - Frontiers
May 7, 2026 · Simvastatin and atorvastatin facilitates amyloid β-protein degradation in extracellular spaces by increasing neprilysin …
Astrocyte biomarker signatures of amyloid-β and tau pathologies in ...
Aug 10, 2022 · Astrocytes can adopt multiple molecular phenotypes in the brain of Alzheimer’s disease (AD) patients. Here, we …
Amyloid-β accumulation in human astrocytes induces ... - Springer
Feb 20, 2023 · Astrocytes play a central role in maintaining brain energy metabolism, but are also tightly connected to the …
The role of astrocytes in amyloid production and Alzheimer's disease
Dec 13, 2017 · It was thought that neuronal cells were the major source of Aβ. However, mounting evidence suggests that astrocytes …
Amyloid-β deposits in human astrocytes contain truncated and highly ...
Mar 1, 2024 · Using a battery of experimental techniques, including mass spectrometry, western blot, ELISA and electron microscopy …
Astrocytes clear amyloid plaques and preserve cognitive function in ...
Nov 21, 2025 · The mechanism involves recruiting brain cells known as astrocytes, star-shaped cells in the brain, to remove the toxic …
Unravelling the spatiotemporal dynamics of amyloid-
Apr 29, 2026 · These findings demonstrate how astrocyte–neuron crosstalk and diffusion-driven instabilities contribute to emergent …
Amyloid-β accumulation in human astrocytes induces mitochondrial ...
Astrocytes play a central role in maintaining brain energy metabolism, but are also tightly connected to the pathogenesis of …