Oct 1, 2025 · Macrophages ingest cholesterol and become foam cells, triggering sustained inflammation and immune activation. This …

In AS, NETs and macrophages establish a self-sustaining vicious cycle—initiated by lipid infiltration, perpetuated through foam cell …

Oct 20, 2023 · In this complex scenario of atherosclerosis, macrophages participate in the whole process, including the initiation, …

Taken together, this study by Dhawan et al. describes a novel pathway by which ER stress in lipid-laden macrophages impacts the …

Dec 16, 2025 · MAT2A-mediated methionine metabolism is enhanced in monocytes/macrophages from patients and mice with …

Jan 20, 2024 · The development and rupture of atherosclerotic plaques is a major contributor to myocardial infarctions and ischemic …

The rupture of an atherosclerotic plaque cap overlying a lipid pool and/or necrotic core can lead to thrombotic cardiovascular events. …

Apr 29, 2026 · This review summarizes the recent advances in human plaque single-cell, spatial transcriptomic, and integrative multi …

Jun 9, 2022 · The risk of rupture and subsequent thrombosis is, among others, determined by vulnerable plaque characteristics and …

Feb 24, 2024 · Continuous release of NETs in response to external stimuli leads to activation of surrounding platelets and …