Jul 4, 2022 · We utilized this platform to evaluate the dose-dependent short- and long-term effects of harmine on β-cell proliferation …

Jul 10, 2024 · Harmine, an orally bioavailable, naturally occurring compound, is the best studied and a highly potent DYRK1A …

Mar 9, 2015 · Using three different mouse and human islet in vivo–based models, we show that harmine is able to induce beta cell …

Nov 9, 2022 · Beta-cell replication to replace lost cells may be achieved by using small-molecule mitogenic drugs, like harmine. …

Dec 20, 2018 · We explore the underlying mechanisms that drive this remarkable rate of proliferation and show that the results apply …

This document provides a comprehensive technical overview of harmine's mechanism of action, quantitative efficacy, and the …

Jun 1, 2022 · Here, we establish a novel method for evaluating compound effects on β-cell proliferation and count using …

Dec 2, 2024 · Although the DYRK1A inhibitors, either alone or in combination with GLP-1 receptor agonists (GLP-1) or transforming …

Mar 1, 2025 · We and others showed that small molecule inhibitors of DYRK1A such as harmine is able to induce human beta cell …

This guide provides an objective comparison of harmine, a plant-derived β-carboline alkaloid, and its role in promoting beta-cell …