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  1. Senecavirus - Wikipedia

    • Senecavirus is a genus of viruses in the order Picornavirales, in the family Picornaviridae. Pig and maybe also cow serve as natural hosts. There is only one species in this genus: Senecavirus A. Senecavirus is a replication-competent oncolytic picornavirus. It has selective tropism for cancers with neuroendocrine features including small cell lung cancer (SCLC) … See more

    Life cycle

    Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment of the virus to host receptors, … See more

    Discovery and origin

    The complete genome sequence of senecavirus was completed in 2008.
    An infectious clone of senecavirus was reported in 2012.
    Senecavirus has been proposed to attack cancer ste… See more

    Image result for senecavirus a. Size: 155 x 200. Source: renci.org
    Image result for senecavirus a. Size: 157 x 89. Source: vetmed.iastate.edu
    Clinical trials

    The initial isolate is being developed as an anti-cancer therapeutic by virtual company Neotropix, Inc. under the name NTX-010.
    Phase I
    • Safety study of senecavirus in patients with solid t… See more

    Virus replication

    Senecavirus uses the anthrax toxin receptor 1 (ANTXR1) protein as a receptor. A high-resolution structure of senecavirus with this receptor has been published. See more

    External links

    Structure of Seneca Valley Virus-001 — on Virus Particle ExploreR (VIPERdb)
    Viralzone: Senecavirus
    ICTV See more

     
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    Jul 1, 2016 · Senecavirus A (SVA) is the only member of the genus Senecavirus within the family Picornaviridae. This virus was discovered as a serendipitous finding in 2002 (and named Seneca Valley virus 001 [SVV-001]) while …

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