Front Microbiol. 2018; 9: 940. Seneca Valley virus (SVV) has recently caused many vesicular diseases in pigs in different regions and countries. As a newly causative agent of porcine vesicular disease, SVV has evolved and spread quickly. It causes clinical signs similar to those of foot-and-mouth disease and results in significant economic losses.

Seneca Valley Virus (SVV) is a disease circulating in pigs. The clinical signs associated with SVV in pigs include vesicles (blisters) or erosions (results of ruptured vesicles) on a pig’s snout, mouth, or feet where the hoof meets the skin.

Seneca Valley virus infection causes vesicular disease that is indistinguishable from the clinical signs of FMD, swine vesicular disease, vesicular stomatitis, or vesicular exanthema ( Leme et al., 2015 ).

Seneca Valley virus disease is important as a differential diagnosis for high-consequence transboundary animal diseases, including foot-and-mouth disease, swine vesicular disease, and vesicular exanthema of swine, from which it is clinically indistinguishable.