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  1. Studies of seneca valley virus treatment
    National Center for Biotechnology Information
    Review of Seneca Valley Virus: A Call for Increased Surveillance and Research
    Seneca Valley virus (SVV) has recently caused many vesicular diseases in pigs in different regions and countries. As a newly causative agent of porcine vesicular disease, SVV has evolved and spread quickly. It causes clinical signs similar to those
    Author: Xiangle Zhang…
    Published: 2018
    Publication: Front Micr…
    National Center for Biotechnology Information
    Senecavirus A as an Oncolytic Virus: Prospects, Challenges and Development Directions
    Oncolytic viruses have the capacity to selectively kill infected tumor cells and trigger protective immunity. As such, oncolytic virotherapy has become a promising immunotherapy strategy against cancer. A variety of viruses from different families have
    Author: Dankun Luo, H…
    Published: 2022
    Publication: Front Onc…
    National Center for Biotechnology Information
    Seneca Valley Virus, a Systemically Deliverable Oncolytic Picornavirus, and the Treatment of Neuroendocrine Cancers
    Background Numerous clinical trials have demonstrated that oncolytic viruses can elicit antitumor responses when they are administered directly into localized cancers. However, the treatment of metastatic disease with oncolytic viruses has been challenging
    Author: P. Seshidhar …
    Published: 2007/11/11
    DOI: 10.1093/jnci/djm198
    PubMed
    Seneca Valley virus, a systemically deliverable oncolytic picornavirus, and the treatment of neuroendocrine cancers
    Background: Numerous clinical trials have demonstrated that oncolytic viruses can elicit antitumor responses when they are administered directly into localized cancers. However, the treatment of metastatic disease with oncolytic viruses has been challenging
    Author: P Seshidhar R…
    Published: 2007/11/07
    Keywords: Numerous …
    PubMed
    A Randomized Double-Blind Phase II Study of the Seneca Valley Virus (NTX-010) versus Placebo for Patients with Extensive-Stage SCLC (ES SCLC) Who Were Stable or Responding after at Least Four Cycles of Platinum-Based Chemotherapy: North Central Cancer Treatment Group (Alliance) N0923 Study
    Introduction: The Seneca Valley virus (NTX-010) is an oncolytic picornavirus with tropism for SCLC. This phase II double-blind, placebo-controlled trial evaluated NTX-010 in patients with extensive-stage (ES) SCLC after completion of first-line
    Author: Erin L Schenk
    Published: 2020/1
    Keywords: The Senec…
    National Center for Biotechnology Information
    Persistent Infection and Transmission of Senecavirus A from Carrier Sows to Contact Piglets
    Persistent viral infections have significant implications for disease control strategies. Previous studies demonstrated the persistence of SVA RNA in the tonsil of experimentally or naturally infected animals long after resolution of the clinical disease.
    Author: Mayara F. Ma…
    Published: 2019/11/11
    Publication: J Virol. 20…
    PubMed
    Seneca Valley virus enters cells through multiple pathways and traffics intracellularly via the endolysosomal pathway
    Seneca Valley virus (SVV, also known as Senecavirus A), an oncolytic virus, is a nonenveloped, positive-strand RNA virus and the sole member of the genus Senecavirus within the family Picornaviridae. The mechanisms of SVV entry into cells are currently
    Author: Wenqiang Liu
    Published: 2023/3
    Keywords: Rab GTPa…
    National Center for Biotechnology Information
    Evolving role of seneca valley virus and its biomarker TEM8/ANTXR1 in cancer therapeutics
    Oncolytic viruses have made a significant inroad in cancer drug development. Numerous clinical trials are currently investigating oncolytic viruses both as single agents or in combination with various immunomodulators. Oncolytic viruses (OV) are an integral
    Author: Virginia Corbet…
    Published: 2022
    Publication: Front Mol …
    National Center for Biotechnology Information
    A randomized double-blind phase II study of the Seneca Valley Virus (NTX-010) vs placebo for patients with extensive stage SCLC (ES-SCLC) who were stable or responding after at least 4 cycles of platinum-based chemotherapy: NCCTG (Alliance) N0923 Study
    Small cell lung cancer (SCLC) is an aggressive malignancy and the majority of patients present with disseminated disease[1]. Patients often experience a significant tumor response to first line therapy but invariably the disease recurs. Additional or
    Author: Erin L. Schenk…
    Published: 2020/01
    DOI: 10.1016/j.jtho.201…
    PubMed
    Phase I clinical study of Seneca Valley Virus (SVV-001), a replication-competent picornavirus, in advanced solid tumors with neuroendocrine features
    Purpose: Seneca Valley Virus (SVV-001) is a novel naturally occurring replication-competent picornavirus with potent and selective tropism for neuroendocrine cancer cell types, including small cell lung cancer. We conducted a first-in-human, first-in-class
    Author: Charles M Rudin
    Published: 2011/02/15
    Keywords: Seneca Val…
    National Center for Biotechnology Information
    A 5-Year Review of Senecavirus A in China since Its Emergence in 2015
    Senecavirus A (SVA), previously known as Seneca Valley virus, is classified into the genus Senecavirus in the family Picornaviridae. This virus can cause vesicular disease and epidemic transient neonatal losses in swine. Typical clinical signs include
    Author: Fuxiao Liu, Qi…
    Published: 2020
    Publication: Front Vet …
     
  2. Merck Veterinary Manual
    https://www.merckvetmanual.com/generalized...

    Seneca Valley Virus Disease in Pigs

     
  3. Swine Health Information Center
    https://www.swinehealth.org/wp-content/uploads/...
    [PDF]

    SENECAVIRUS A - Swine Health

  5. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958643

    Review of Seneca Valley Virus: A Call for Increased Surveillance …

  6. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968071

    Senecavirus A as an Oncolytic Virus: Prospects, Challenges and ...

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    Seneca Valley Virus
    Oncolytic virus
    Published:2022
  7. Swine Health Information Center
    http://www.swinehealth.org/.../03/Seneca-Valley-virus-fact...
    [PDF]

    SENECA VALLEY VIRUS

  8. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5261858

    Seneca Valley Virus, a Systemically Deliverable Oncolytic …

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    Seneca Valley School District
    Oncolytic virus
    Seneca Valley Virus Vp1 Sequence
  9. People also ask
    Does Seneca Valley virus treat neuroendocrine cancer?
    PS Reddy, et al., Seneca Valley virus, a systemically deliverable oncolytic picornavirus, and the treatment of neuroendocrine cancers. J Natl Cancer Inst 99, 1623–1633 (2007). CM Rudin, et al., Phase I clinical study of Seneca Valley virus (SVV-001), a replication-competent picornavirus, in advanced solid tumors with neuroendocrine features.

    Structural basis for anthrax toxin receptor 1 recognition by ... - PNAS

    pnas.org
    Does Seneca Valley virus cause neonatal mortality?
    (B) SVV virions observed using electron microscopy. Seneca Valley virus infection has also been associated with pig neonatal mortality [recently named epidemic transient neonatal losses (ETNLs)], especially in pig herds with SVV-affected sows ( Canning et al., 2016; Gimenez-Lirola et al., 2016; Leme et al., 2016b ).

    Review of Seneca Valley Virus: A Call for Increased Surveillance and Re…

    ncbi.nlm.nih.gov
    Does Seneca Valley virus 3C protease negatively regulate the type 1 interferon pathway?
    Seneca Valley Virus 3C Protease Negatively Regulates the Type I Interferon Pathway by Acting as a Viral Deubiquitinase. Antiviral Res (2018) 160:183–9. doi: 10.1016/j.antiviral.2018.10.028 [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar]

    Senecavirus A as an Oncolytic Virus: Prospects, Challenges and Develo…

    ncbi.nlm.nih.gov
    How is SVV diagnosed?
    Diagnosis of SVV is crucial for SVV control and prevention. Diagnosis of SVV could be performed by detection of virus, viral antigens, or viral RNA. Many types of cells have been used for isolation of SVV, including human cancer, swine, and engineering cell lines.

    Review of Seneca Valley Virus: A Call for Increased Surveillance and Re…

    ncbi.nlm.nih.gov
    Feedback
  10. PubMed
    https://pubmed.ncbi.nlm.nih.gov/17971529

    Seneca Valley virus, a systemically deliverable oncolytic …

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    Oncolytic virus
    Seneca Valley Virus Vp1 Sequence
    Seneca Valley virus-001
  11. PubMed
    https://pubmed.ncbi.nlm.nih.gov/31605793

    A Randomized Double-Blind Phase II Study of the Seneca Valley …

    Tags:
    Seneca Valley School District
    Seneca Valley Virus
    Oncolytic virus
  12. College of Agriculture & Natural Resources
    https://www.canr.msu.edu/seneca_vall…

    Seneca Valley Virus

    WEBSeneca Valley Virus (SVV) is a disease circulating in pigs. The clinical signs associated with SVV in pigs include vesicles (blisters) or erosions (results of ruptured vesicles) on a pig’s snout, mouth, or feet where the …

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    Seneca Valley School District
    Seneca Valley Virus Incubation Period
  13. Cell Press
    https://www.cell.com/molecular-therapy-family/...

    725. Seneca Valley Virus, a Novel Systemically Deliverable …

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    Seneca Valley Virus
    Oncolytic virus
  14. Frontiers
    https://www.frontiersin.org/journals/microbiology/...

    Frontiers

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    Seneca Valley School District
    Seneca Valley Disease
    Seneca Valley Pigs
  15. PNAS
    https://www.pnas.org/doi/10.1073/pnas.1810664115

    Structural basis for anthrax toxin receptor 1 recognition by Seneca ...

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    Seneca Valley School District
    Seneca Valley Virus
    Oncolytic virus
  16. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803263

    Persistent Infection and Transmission of Senecavirus A from …

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    Publish Year:2019
    Published:2019/11/11
  17. Veterinary Diagnostic Laboratory
    https://vetmed.iastate.edu/.../pathogens/senecavirus

    Senecavirus A

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    Seneca Valley Virus Incubation Period
    Covid-19
    Senecavirus A Pigs
  18. Cell Press
    https://www.cell.com/molecular-therapy-family/...

    291. In Vivo Characterization of Seneca Valley Virus (SVV-001), a …

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    Seneca Valley School District
    Seneca Valley Virus
    Oncolytic virus
  19. PubMed
    https://pubmed.ncbi.nlm.nih.gov/36947577

    Seneca Valley virus enters cells through multiple pathways and ...

    Tags:
    Seneca Valley virus-001
    Infection
  20. Swine Health Information Center
    http://www.swinehealth.org/.../03/Seneca-Valley-Virus.pdf
    [PDF]

    SENECA VALLEY VIRUS

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    Seneca Valley Virus
    Svv Swine
  21. ScienceDirect
    https://www.sciencedirect.com/.../seneca-valley-virus

    Seneca Valley Virus - an overview

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    Seneca Valley School District
    Seneca Valley Virus
  22. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458967

    Evolving role of seneca valley virus and its biomarker …

    Tags:
    Oncolytic virus
    Review of Seneca Valley Virus
    Published:2022
  23. ScienceDaily
    https://www.sciencedaily.com/releases/2007/10/071030160940.htm

    Cancer-Killing Virus Shows Promise as Metastatic Cancer …

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    Cancer Treatment
    Virus
  24. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279615

    A randomized double-blind phase II study of the Seneca Valley …

    Tags:
    Seneca Valley School District
    Seneca Valley Virus
    Oncolytic virus
  25. Salt Lake County
    https://slco.org/health/news/wnv2024

    West Nile Virus Detected in Salt Lake County - Health Department

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    United States Department of Health and Human Services
    Salt Lake County
  26. PubMed
    https://pubmed.ncbi.nlm.nih.gov/21304001

    Phase I clinical study of Seneca Valley Virus (SVV-001), a ...

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    Seneca Valley School District
    Seneca Valley Virus Vp1 Sequence
    Rego Center
  27. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561413

    A 5-Year Review of Senecavirus A in China since Its Emergence …

    Tags:
    Seneca Valley Virus
    Seneca Valley Disease
    Publish Year:2020
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