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  1. Melanin is the product of a complex biochemical pathway called melanogenesis and it can undertake two chemically distinct forms: the black to brown eumelanic form and the reddish-brown to yellow pheomelanic form. Melanin is then transferred to the surrounding keratinocytes that will proliferate and differentiate originating hair shafts.

    A Comprehensive Review of Mammalian Pigmentation: Paving th…

    www.ncbi.nlm.nih.gov/pmc/articles/PMC9953601/
    www.ncbi.nlm.nih.gov/pmc/articles/PMC9953601/
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  2. People also ask
    Does human hair pigmentation affect follicle melanocytes?
    Human hair pigmentation--biological aspects. Int J Cosmet Sci. 2008 Aug;30 (4):233-57. doi: 10.1111/j.1468-2494.2008.00456.x.Int J Cosmet Sci. 2008. Human hair greying is linked to a specific depletion of hair follicle melanocytes affecting both the bulb and the outer root sheath.

    Hair Cycle and Hair Pigmentation: Dynamic Interactions and Changes

    pubmed.ncbi.nlm.nih.gov
    What are the causes of pigmentation?

    Dr. ANUVITHA KAMATH

    MBBS · 3 years of exp

    Pigmentation is the unusual darkening of the skin compared to the surrounding areas, due to the presence of excess melanin pigment that gives a darker complexion. The causes of skin pigmentation can be the hereditary-genetic history of freckles. The other causes are hormone changes during pregnancy or post-menopause, adrenal gland disorders like Addison's disease, melasma, oral contraceptive pills, post-injury to the skin, acne formation, sunburns, thyroid disorders, and vitamin B12 deficiency.
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    How does melanogenesis affect hair follicles?
    Melanogenesis during the anagen phase is coupled with the precise regulatory network controlling hair growth, so leading to the pigmented hair shaft. The melanocyte component in hair follicles is more sensitive to aging influences than melanocytes in the epidermis .

    Signaling Pathways in Melanogenesis - PMC

    pmc.ncbi.nlm.nih.gov
    What causes pigmentation in hair follicles?
    In the adult hair follicle, pigmentation results from precise sequential interactions between follicular melanocytes, matrix keratinocytes, and dermal papilla (DP) fibroblasts ( Slominski and Paus, 1993 ).

    Hair Follicle Pigmentation - ScienceDirect

    sciencedirect.com
    What is follicular melanogenesis?
    Follicular melanogenesis (FM) involves sequentially the melanogenic activity of follicular melanocytes, the transfer of melanin granules into cortical and medulla keratinocytes, and the formation of pigmented hair shafts.

    Hair Follicle Pigmentation - Journal of Investigative Dermatology

    jidonline.org
    What factors affect follicular pigmentation?
    Despite this, follicular pigmentation is still responsive to numerous intrinsic factors including: hair cycle-dependent changes, body distribution, racial and gender differences, variable hormone responsiveness, genetic defects and age-associated change [ 19, 20, 47 ].

    Human hair pigmentation – biological aspects - Tobin - 2008

    onlinelibrary.wiley.com
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  3. Journal of Investigative Dermatology
    https://www.jidonline.org/article/S0022-202X(15)32108-4/fulltext

    Hair Follicle Pigmentation - Journal of Investigative Dermatology

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  4. Studies of melanogenic hair follicle pigmentation
    PubMed
    Hair follicle pigmentation - PubMed
    Hair shaft melanin components (eu- or/and pheomelanin) are a long-lived record of precise interactions in the hair follicle pigmentary unit, e.g., between follicular melanocytes, keratinocytes, and dermal papilla fibroblasts. Follicular melanogenesis (FM) involves sequentially the melanogenic activi...
    Author: Andrzej Slomi…
    Published: 2005/1
    Keywords: National In…
    ScienceDirect
    Review Graying: gerontobiology of the hair follicle pigmentary unit
    The visual appearance of humans derives predominantly from their skin and hair color. The phylogenetical pathway underling this phenomenon is called melanogenesis and results in the production of melanin pigments in neural crest-derived melanocytes, followed by its transfer to epithelial cells. Whil...
    Published: 2001/01/01
    Cited By: 0
    Keywords: Graying; M…
    PubMed
    Hair cycle and hair pigmentation: dynamic interactions and changes associated with aging
    The tight coupling of hair follicle melanogenesis to the hair growth cycle dramatically distinguishes follicular melanogenesis from the continuous melanogenesis of the epidermis. Cyclic re-construction of an intact hair follicle pigmentary unit occurs optimally in all scalp hair follicles during onl...
    Author: Dominique Va…
    Published: 2004
    Keywords: National In…
    PubMed
    Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity
    The visual appearance of humans is derived significantly from our skin and hair color. While melanin from epidermal melanocytes protects our skin from the damaging effects of ultraviolet radiation, the biological value of pigmentation in the hair follicle, particularly on the scalp, is less clear. I...
    Author: Cristina Casalou
    Published: 2023/08/15
    Keywords: C-KIT; MIT…
    National Center for Biotechnology Information
    Hair Follicle Pigmentation - PMC - National Center for Biotechnology ...
    Hair shaft melanin components (eu- or/and pheomelanin) are a long-lived record of precise interactions in the hair follicle pigmentary unit, e.g., between follicular melanocytes, keratinocytes, and dermal papilla fibroblasts. Follicular melanogenesis (FM) involves sequentially the melanogenic activi...
    Author: Andrzej Slomi…
    Published: 2005/01
    DOI: 10.1111/j.0022-20…
  5. PubMed
    https://pubmed.ncbi.nlm.nih.gov/15654948

    Hair follicle pigmentation - PubMed

    Tags:
    Hair Follicle Melanin
    Publish Year:2005
    Melanin Transfer At The Hair Shaft
  6. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC6290285

    Premature Graying of Hair: Review with Updates - PMC

    Tags:
    Hair Follicle Pigmentation
    Canadian Parliamentary Review
    Hair Follicle Growth
  7. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC4964517

    Signaling Pathways in Melanogenesis - PMC

    Tags:
    Melanogenesis in Hair
    Melanocyte

  8. Images of Melanogenic Hair Follicle Pigmentation

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  9. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S2950575524000078

    The biology and molecular regulation of MeSCs in hair follicles …

    Tags:
    Human Hair Pigmentation
    Biology
  10. Wiley Online Library
    https://onlinelibrary.wiley.com/doi/full/10.11…

    Human hair pigmentation – biological aspects - Tobin

    Jul 11, 2008 · Despite many shared features, follicular melanocytes appear to be more sensitive than epidermal melanocytes to ageing influences. This can be seen most dramatically in hair greying/canities and this is likely to reflect …

    Tags:
    Hair Follicle Pigmentation
    Hair Color
    Human Hair Pigmentation
  11. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC1201498

    Hair Follicle Pigmentation - PMC

    Tags:
    Hair Follicle Pigmentation
    Hair Follicle Melanin
  12. Journal of Investigative Dermatology
    https://www.jidonline.org/article/S0022-202X(15)32108-4/pdf
    [PDF]

    Hair Follicle Pigmentation - jidonline.org

    Tags:
    Hair Follicle Pigmentation
    Tobin
  13. Springer
    https://link.springer.com/chapter/10.1007/978-3-540-46911-7_4

    Biology of Hair Follicle Pigmentation | SpringerLink

    Tags:
    Hair Follicle Pigmentation
    Desmond J. Tobin
    Publish Year:2008
  14. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S0022202X15321084

    Hair Follicle Pigmentation - ScienceDirect

    Tags:
    Hair Follicle Pigmentation
    Hair Follicle Melanin
    Publish Year:2005
  15. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S0531556500002102

    Graying: gerontobiology of the hair follicle pigmentary unit

    Tags:
    Hair Follicle Pigmentation
    Hair Color
    D.J Tobin, R Paus
    Publish Year:2001
  16. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC2938584

    Aging of the Hair Follicle Pigmentation System - PMC

  17. PubMed
    https://pubmed.ncbi.nlm.nih.gov/15036274

    Hair cycle and hair pigmentation: dynamic interactions and …

    Tags:
    Hair Follicle Growth Cycle
    Hair Cycle and Hair Pigmentation
    Publish Year:2004
  18. Wiley Online Library
    https://onlinelibrary.wiley.com/doi/10.1111/j.1755-148X.2010.00803.x

    The cell biology of human hair follicle pigmentation

    Tags:
    Hair Follicle Pigmentation
    Human Hair Pigmentation
    Desmond J. Tobin
  19. MDPI
    https://www.mdpi.com/1422-0067/24/16/12809

    Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen …

    Tags:
    Homo sapiens
    Capacity
  20. PubMed
    https://pubmed.ncbi.nlm.nih.gov/37628992

    Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen …

  21. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC7308992

    Recent advances in understanding the molecular basis of …

    Tags:
    Hair Color
    Melanin
  22. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1201498

    Hair Follicle Pigmentation - PMC - National Center for …

    Tags:
    Hair Follicle Pigmentation
    Hair Follicle Melanin
    Publish Year:2005
  23. Wiley Online Library
    https://onlinelibrary.wiley.com/doi/full/10.1111/j.1600-0625.2008.00804.x

    Human hair follicle pigmentary unit as a direct target for …

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    Jean-François Michelet, Brigitte Gautier, Olivier Gaillard, Bruno Alain Bernard, Florence Benech
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