In February 2006, Chandler returned to television to guest star as the ill-fated bomb squad leader Dylan Young in two episodes of the ABC series Grey's Anatomy. The episodes, titled "It's The End of The World" and "As We Know It", followed Super Bowl XL.

Kyle Chandler, now 55, was the most notable guest star in the episodes, playing Dylan Young, the Bomb Squad Guy who assists Meredith in trying to make sure the bomb inside a patient’s chest doesn’t explode and kill them all.