Interstate 80 (I-80) is an east–west transcontinental freeway that crosses the United States from San Francisco, California, to Teaneck, New Jersey, in the New York metropolitan area. The highway was designated in 1956 as one of the original routes of the Interstate Highway System; its final segment was opened in 1986.

This article is about the section of Interstate 80 in Pennsylvania. For the entire route, see Interstate 80. Interstate 80 (I-80) in the US state of Pennsylvania runs for 311.12 miles (500.70 km) across the central part of the state. It is designated as the Keystone Shortway and officially as the Z.H. Confair Memorial Highway.

The 45 mile long project widening Interstate 80 from four to six lanes extended from just west of NW 48th Street in West Lincoln (Exit 395) to the N-370 interchange (Exit 439) in West Omaha.

In 1966, Interstate 80 opened from Exit 29 to Exit 42, Exit 242 to Exit 256, and Exit 273 to Exit 293.