Inside, the two- or three-level houses commonly feature crown molding, a dedicated entryway with centered hallway and a grand stairway. Their spacious scale allows for ample kitchen and living areas, multiple bedrooms, and den/office rooms, along with a full basement.'

Colonial-style decor evokes a feeling of stately elegance. The interior often features a grand entrance hall, wide staircase, polished wood floors, millwork, and wainscoting. Fireplaces were also focal points in the room.

The first floor of a colonial focuses on socializing, with a moderate-to-large-sized kitchen and common areas like living and dining rooms. The second floor comprises bedrooms and bathrooms, with a wide staircase usually in the center of the home. If there is a third floor, there might be additional bedrooms.

Today, many colonial-style houses have two rooms, have all bedrooms on the second floor, and boast an open entrance that is two stories tall. A centralized staircase is located in the entry, and on either side of the entryway is a formal dining room and formal living room. The kitchen and family room are located in the back half of the house.

The layout of modern Colonial homes creates plenty of space for large families to reside in, often with four upstairs bedrooms and finished basements that offer additional space to host guests and recreational rooms. Their main living areas, like many other homes from the era, are laid out to largely focus around the kitchen and den.