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- Missense mutationIt seems that the dendritic localization of Flamingo protein is essential for proper dendrite morphogenesis because a missense mutation that causes the Flamingo protein to fail to localize to the dendrites and axons leads to overextension of dorsal dendrites.
www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/fla… - See more
See all on WikipediaFlamingo (protein) - Wikipedia
In Drosophila, flamingo mutants were found to have abnormal dendrite branching, outgrowth and routing. Kimura et al. proposed that flamingo regulates dendrite branch elongation and prevents the dendritic trees of adjacent Drosophila sensory neurons from having overlap of dendritic arbors. A study of mammalian … See more
Flamingo is a member of the adhesion-GPCR family of proteins. Flamingo has sequence homology to cadherins and G protein-coupled receptors (GPCR). Flamingo was originally identified as a Drosophila protein … See more
Flamingo is one of the core proteins in the planar cell polarity (PCP) pathway, which is required for successful body elongation during gastrulation in early development, as well as the formation of developing organs such as the brain, inner ear, and kidney. It has been … See more
Flamingo is an atypical cadherin, with a cadherin-like extracellular domain, composed of cadherin and EGF adhesive repeats, that can bind to other Flamingo proteins expressed on neighboring cells. The transmembrane domain, however, is a 7-pass membrane … See more
Wikipedia text under CC-BY-SA license The seven-pass transmembrane cadherin Flamingo controls …
Sep 9, 2011 · Here we show that a LIM domain protein, Espinas (Esn), binds to an intracellular juxtamembrane domain of Flamingo (Fmi), and that this Fmi–Esn interplay elicits repulsion …
- Author: Daisuke Matsubara, Shin-ya Horiuchi, Kohei Shimono, Tadao Usui, Tadashi Uemura
- DOI: 10.1101/gad.16531611
- Publish Year: 2011
- Publication: Genes Dev. 2011 Sep 15; 25(18): 1982-1996.
Planar cell polarity genes, Celsr1-3 , in neural development
flamingo is among the ‘core’ planar cell-polarity genes, protein of which belongs to a unique cadherin subfamily. ... Usui T., Tsubouchi A., Uemura T. Potential dual molecular interaction of …
Flamingo (Protein) - an overview | ScienceDirect Topics
It seems that the dendritic localization of Flamingo protein is essential for proper dendrite morphogenesis because a missense mutation that causes the Flamingo protein to fail to …
Regulation of Dendritic Maintenance and Growth by a …
Aug 1, 2004 · Phenotypic analysis of flamingo (fmi) mutants has shown pleiotropic roles of Fmi in controlling epithelial and neuronal cell morphogenesis. In epithelia, Fmi regulates planar cell …
- Author: Yasuyuki Shima, Mineko Kengaku, Tomoo Hirano, Masatoshi Takeichi, Tadashi Uemura
- Publish Year: 2004
The atypical cadherin flamingo determines the competence of …
We found that the topographic defect caused by loss of fmi was epistatic to the inhibition of neuronal activity and the overexpression of the activity-regulated gene Trim9. These results …
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Control of Dendritic Field Formation in Drosophila
In flamingo loss-of-function mutants, the extension of dendrites fail to stop short of the dorsal midline during embryogenesis. An important question is whether the function of flamingo in shaping the dendritic fields is cell autonomous.
Control of dendritic field formation in Drosophila: the roles of ...
The formation of normal dendritic fields and the competition between dendrites of homologous neurons require the proper expression level of Flamingo, a G protein-coupled receptor-like …
Dentritic Growth: Neuron - Cell Press
A simple model to explain the effects of flamingo mutations on dendritic restriction at the dorsal midline is to postulate that md neurons express both the Flamingo receptor and its ligand on dendrites, and that ligand–receptor interactions …
Flamingo Regulates R8 Axon-Axon and Axon-Target …
May 13, 2003 · In a genetic screen for mutants with abnormal R cell connectivity, we recovered mutations in flamingo (fmi). fmi encodes a seven-transmembrane cadherin, previously shown to function in planar cell polarity [2] and in …
Control of Dendritic Field Formation in Drosophila - ScienceDirect
Oct 1, 2000 · The findings that Flamingo restricts dorsal dendrite extension and Flamingo is involved in preventing overlap of dendritic fields of homologous neurons have provided an …
Caenorhabditis elegans Flamingo FMI-1 controls dendrite self …
Jul 31, 2020 · Here, we show that FMI-1/Flamingo, an atypical cadherin, is required autonomously for self-avoidance in the multidendritic PVD neuron of Caenorhabditis elegans. The fmi-1 …
Flamingo (protein) - bionity.com
In Drosophila, flamingo mutants were found to have abnormal dendrite branching, outgrowth and routing. Kimura et al proposed that flamingo regulates dendrite branch elongation and …
Flamingo participates in multiple models of cell competition
Dec 30, 2024 · In Drosophila, the planar cell polarity protein Flamingo is required by winners to maintain their status during cell competition in multiple models as they compete to occupy …
Study Of Flamingo Genes Reveals Surprising Family Tree
Jul 13, 2001 · A comprehensive analysis of the genes of aquatic birds has revealed a family tree dramatically different from traditional relationship groupings based on the birds' body structure, …
Caenorhabditis elegans Flamingo FMI-1 controls dendrite self
Jul 31, 2020 · FMI-1 downregulates VANG-1 levels probably through forming protein complexes. Our study identifies molecular links between Flamingo and the F-actin cytoskeleton that …
Left/right asymmetrically expressed ephrin and Flamingo proteins ...
Jan 1, 2025 · Here, by combining a candidate approach and single-cell RNA sequencing data analysis, we identify the ephrin protein EFN-2 and the Flamingo protein FMI-1 as downstream …
10.1006/dbio.2002.0702 | 10.1006/dbio.2002.0702 - DeepDyve
Jun 11, 2020 · The dendritic overextension phenotype was partially conferred by the precocious initiation of dorsal dendrites in flamingo mutant embryos. In addition, Flamingo is required cell …
Flamingo participates in multiple models of cell competition - eLife
This study investigates the role of the Cadherin Flamingo (Fmi) in cell competition in developing tissues in Drosophila melanogaster. The findings are valuable in that they show that Fmi is …
NF-κB RelB suppresses the inflammatory gene expression
4 days ago · NF-κB RelB suppresses the inflammatory gene expression programs of dendritic cells by competing with RelA for binding to target gene promoters Cell Discov. 2025 Feb 11 ...
Dendritic cell maturation in cancer | Nature Reviews Cancer
Feb 7, 2025 · Dendritic cells (DCs) shape the adaptive immune response to peripheral tissue antigens and, as such, are crucial for mounting an effective antitumour immune response in …
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