As per the norm in The Matrix Trilogy, the Agents in the film can be seen wielding Desert Eagle Mark XIX pistols in .50 AE. Smith (Hugo Weaving) uses them to terrifying effect when a group of his clones, all carrying identical Desert Eagles, volley fire them at Neo, Morpheus, and the Keymaker (Randall Duk Kim).

Trinity (Carrie-Anne Moss) carries a pair of Beretta 92FS Compact pistols as her sidearms in this film and The Matrix Revolutions (although she is only seen using one in this film). She pulls one of her Berettas on Persephone (Monica Bellucci) when she desires to kiss Neo (Keanu Reeves).

Agent Smith returned in The Matrix Reloaded, and he had some new abilities, too. He and his human rival Neo came face to face in a small urban park, where Smith explained himself and Neo coolly listened. Then they traded blows, and the resulting battle was unlike anything from the previous movie.

She pulls one of her Berettas on Persephone (Monica Bellucci) when she desires to kiss Neo (Keanu Reeves). She later pulls one of them and fires it into one Twin's arm when he blocks open a door leading to a parking garage. The screen used Beretta 92FS Compact pistols in the film The Matrix Reloaded.