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Insulin- Pharmacology, Therapeutic Regimens and Principles of Intensive Insulin Therapy
- Published: 2023/02/15
- Authors: Thomas Donnor, Sudipa Sarkar
- Affiliations: Division of Endocrinology, Diabetes, and Meta…
Since the introduction of insulin analogs in 1996, insulin therapy options for patients with type 1 and type 2 diabetes have expanded. Insulin therapies are now able to more closely mimic physiologic insulin secretion and thus achieve better glycemic control in patients with diabetes. This chapter r...Structural principles of insulin formulation and analog …
Lantus® is the most widely used long-acting insulin currently on the formulary. Increasing the formulated strength of glargine to U-300 (monomer concentration 1.8 mM) further prolongs absorption to provide, at steady-state, a …
An Overview of Concentrated Insulin Products
Aug 1, 2016 · Glargine U-300, sold under the trade name Toujeo, is a long-acting insulin for subcutaneous injection, containing 300 units/mL of insulin glargine. It is approved for use in patients with type 1 or type 2 diabetes.
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Solution structures of long-acting insulin analogues and their
Mar 1, 2019 · The self-association and association with albumin of two insulin analogues, insulin detemir and insulin degludec, were investigated by small-angle X-ray scattering (SAXS) and …
- Author: Line Abildgaard Ryberg, Pernille Sønderby, Fabian Barrientos, Jens T. Bukrinski, Günther H.J. Peters...
- Publish Year: 2019
Structural principles of insulin formulation and analog design: A ...
Oct 1, 2021 · Long-acting insulin conjugates. (A) Insulin detemir contains an aliphatic C-14 group (myristic acid) on Lys B29 on a des -B30 scaffold. (B) Insulin degludec has a more complex …
- Author: Mark A. Jarosinski, Balamurugan Dhayalan, Yen-Shan Chen, Deepak Chatterjee, Nicolás Varas, Michael A...
- Publish Year: 2021
Long Acting Insulin - an overview | ScienceDirect Topics
Long-acting insulin, such as glargine and detemir, is a type of insulin with an extended duration of action, typically lasting up to 20 hours, making it suitable for patients who require a steady …
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Insulin Biosynthesis, Secretion, Structure, and …
Feb 1, 2014 · The T 6 insulin structure defines hydrophobic, solvent-exposed, and potential binding surfaces of insulin. This characterization has been supported by NMR-based solution structures of the insulin hexamer , engineered dimer , …
Molecular structure of long-acting insulin analogs: (A) …
Insulin derivatives such as insulin detemir and insulin degludec are U.S. Food and Drug Administration (FDA)-approved long-acting insulin currently used by millions of people with diabetes.
Molecule of the Month: Designer Insulins - RCSB: …
Long-acting insulins have also been created by attaching long hydrocarbon chains to the hormone. This modification brings together several hexamers, forming an aggregate of insulin hexamers that slowly dissolves in the blood.
[Insulin analogs: structure, properties and therapeutic indication ...
[Insulin analogs: structure, properties and therapeutic indication. Part 2. ... Long-acting insulin analogs] [Insulin analogs: structure, properties and therapeutic indication. Part 2. Long-acting …
Molecular engineering of safe and efficacious oral basal insulin
Recently, the first orally-administered ultra-long acting insulin was shown to have clinical efficacy. Here, the authors report the molecular engineering, as well as the biological and …
Degludec: the new ultra-long insulin analogue - PMC - PubMed …
The new ultra-long insulin analogue degludec (IDeg) has the same amino acid sequence as human insulin except for the removal of threonine in the position 30 of the B chain (Des-B30, …
Molecular structure of long-acting insulin analogs-(a) insulin ...
Insulin degludec is an ultra-long-acting (pharmacokinetic half-life of 25 h) basal insulin designed to achieve a highly stable pharmacodynamic profile, with lower within-day and day-to-day...
Structural Principles of Insulin Formulation and Analog Design: a ...
Aug 1, 2021 · Long-acting insulin conjugates. (A) Insulin detemir contains an aliphatic C-14 group (myristic acid) on Lys B29 on a des-B30 scaffold.
Evolution of Insulin and How it Informs Therapy and Treatment …
May 12, 2020 · Exogenous insulins are now available as rapid-acting, short-acting, intermediate-acting, and long-acting. The timing of insulin action arises from the unique pharmacokinetics …
New Long-Acting Basal Insulins: Does Benefit Outweigh Cost?
Jul 16, 2016 · Figure 2 outlines the chemical structure and modifications derived from the human insulin molecule of insulins glargine (Fig. 2A) and detemir (Fig. 2B) as well as of the three new …
Insulin glargine: a systematic review of a long-acting insulin
Background: Insulin glargine is the first long-acting basal insulin analogue indicated for subcutaneous administration once daily at bedtime in adults with type 1 or type 2 diabetes …
Types of Insulin Chart: Duration, Comparison, and More - Healthline
May 10, 2022 · Types of insulin include rapid-, regular-, intermediate-, and long-acting, based on how long they take to start working. You may take a combination of these when managing …
Long-acting insulin: How to use, types, dosage, and duration
Aug 2, 2023 · Long-acting, or basal, insulin is a slow-acting type of insulin. It can help a person stabilize blood sugar levels throughout the day. Types of long-acting insulin include degludec, …
Insulin glargine: A systematic review of a long-acting insulin …
Jun 1, 2003 · Background: Insulin glargine is the first long-acting basal insulin analogue indicated for subcutaneous administration once daily at bedtime in adults with type 1 or type 2 diabetes …
Regulation and function of insulin and insulin-like growth factor ...
Feb 10, 2025 · The discovery and characterization of insulin–insulin-like growth factor (IGF) receptor signalling have provided unprecedented insight into the relationship between receptor …
Molecular Aspects of Insulin Aggregation and Various …
The slow-acting insulin biosimilar, Glargine, contains an AspA21 to glycine mutation along with addition of two arginine residues at the C-terminus of the B chain. ... stable insulin analogs …
FDA Approves First Rapid-Acting Insulin Biosimilar Product for ...
Feb 14, 2025 · Approximately 8.4 million Americans rely on insulin therapy, either rapid-acting and/or long-acting, to manage diabetes. Insulin, a hormone made by the pancreas, helps …
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