In August 2018, a strategy game titled Disney Villainous was designed by Prospero Hall, published by Ravensburger and released exclusively to Target stores. The game has players compete as Disney Villains attempting to accomplish their goals from the film, while simultaneously trying to slow down their opponents. As of March 2021, four standalone expansions have released, with each adding three different playable villains.

Villain merchandise was available at the former Villains in Vogue store in Sunset Blvd, at Disney's Hollywood Studios. This first store was so successful that the Disneyland Villain Shop was opened afterwards in 1991. Both of these have since now closed.

USAopoly has released a number of products featuring Disney villains. Among them is a Monopoly-based board game called My Disney Villains Monopoly, where the players decide which of 30 villains can appear on each space on the board (characters that appear in the game that are not part of the official Villain list include Beagle Boys, Three Little Wolves, Pom-Pom, Man, Hound Dogs, and Chief); a checkers game; and a collector's card game set.

An online Disney trivia game called Who Wants to be a Villionaire, released in October 2001, is loosely based on Who Wants to Be a Millionaire? and features several villains as hosts, asking questions about the film in which they are featured. The "Phone-a-Friend" feature is renamed "Phone-a-Fiend" and will connect the player to Cruella de Vil.

There is a sub-franchise derived from Disney villains entitled Disney's Divas of Darkness. The line-up includes Maleficent, the Evil Queen, Cruella de Vil, Ursula, and the Queen of Hearts.

The Villains Designer Collection re-imagines the stylish wickedness of Disney villains. This line of merchandise includes Maleficent, Cruella de Vil, the Evil Queen, the Queen of Hearts, Ursula and Mother Gothel.

The Vinylmation collection also includes a Villains series.
Several books dedicated to Disney villains have been released. Among them are:
• Disney Villains: The Top Secret Files by Jeff Kurtti
• Disney's The Villains Collection: Stories from the Films by Todd Strasser
• Disney's Villains: A Pop-Up Book by Walt Disney Company
• Disney Villains: The Essential Guide by DK Publishing
• Disney Villains (Ultimate Sticker Books) by DK Publishing
• Disney Villains: The Essential Guide to the Evilest of Them All by DK Publishing
There are also books to color, like Disney Villains: All the Rage and Disney Villains Giant Book to Color ~ Diabolical Deeds!

Several characters from the Disney villains make meet-and-greet appearances at various Disney Parks locations. Previous parades such as Disney's Hollywood Studios' Disney Stars and Motor Cars Parade, SpectroMagic and Disney's Once Upon a Dream Parade featured a float dedicated to villains, and Parade of Dreams (an Ursula float).

A 1999 exhibit at the Cartoon Art Museum entitled "The Disney Villains" included displays featuring Disney's official villains, along with other villainous characters such as the Hunter from Bambi, and Br'er Fox & Br'er Bear from Song of the South.
Disney villains play a vital role in the nighttime show Fantasmic!, performed at the Disneyland and Disney's Hollywood Studios theme parks. In the shows, the Evil Queen decides it is time to finish off Mickey Mouse once and for all, and invokes other villains to help her.
Disney villains appear in Mickey's Not-So-Scary Halloween Party, a Halloween-themed event held annually during the months of September and October at the Magic Kingdom theme park at Walt Disney World and at Disneyland Paris. A stage show and meet-and-greet with the villains led by Dr. Facilier (and prior to 2011 by Maleficent) titled "The Disney Villains Mix and Mingle" is held on the Cinderella Castle Forecourt Stage. Among those to visit are the Queen of Hearts, Captain Hook, and the Evil Queen among others. During the fireworks show HalloWishes some villains arrive to the celebration, starting with Ursula "plopping in" on the party and adding her own musical mix to the festivities. Jafar and Oogie Boogie soon follow, and arriving last is Maleficent showing the audience how Halloween should really be celebrated.
In the Dream Along with Mickey stage show at Walt Disney World's Magic Kingdom, the Disney villains appear onstage to threaten Mickey Mouse, Minnie Mouse, Donald Duck and Goofy. Maleficent states that since people no longer believe in dreams, it is the perfect time for her to return to power and make the Magic Kingdom "The Place Where Nightmares Come True"—a play on the Disney Experiences slogan of "The Place Where Dreams Come True". She is also accompanied by Captain Hook.
The Disney villains star as the main characters in the Disney Cruise lines' variety show, Villains Tonight. This musical stage production features Hades on a quest to get more evil in the Underworld by summoning up Disney's most powerful villains so he can keep his job. This show features Maleficent, Jafar, the Evil Queen, Cruella de Vil, Captain Hook, Scar, Yzma, Ursula, and Chernabog in a variety of comical situations while performing various musical numbers from their respective appearances. This show debuted on the Disney Magic cruise ship March 27, 2010, and the Disney Dream on January 26, 2012.
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Disney's Villains' Revenge is a 1999 video game which tells the story of how the Evil Queen, Captain Hook, Queen of Hearts, and the Ringmaster change the story from the original movie to the way they wanted the story to end, with no "Happily Ever After".
In the Kingdom Hearts series of action role-playing games developed and published by Disney Interactive Studios and Square Enix, Disney villains play a major role as they seek to harness the power of darkness. The villains are antagonists in different worlds, such as the Villains group led by Maleficent, with Pete as her main henchman, Hades in Olympus, Jafar in Agrabah, Ursula in Atlantica, Oogie Boogie in Halloween Town, Captain Hook in Neverland, and Scar in the Pride Land. Other villain in the group outside the official line-up is Captain Barbossa of Port Royal.

Other Disney Villains in the games are Queen of Hearts in Wonderland, Clayton in Deep Jungle, Chernabog in End of the World & Symphony of Sorcery, Shan Yu in the Land of Dragons, The Evil Queen in Dwarf Woodlands, Lady Tremaine, Anastasia and Drizella in Castle of Dreams, Captain Gantu in Deep Space, Claude Frollo in La Cité des Cloches, Gaston in Beast's Castle, King Candy in Candy Kingdom, Mother Gothel in Kingdom of Corona, Randall Boggs in Monstropolis, and Hans in Arendelle.

Other villains outside the official line-up that also make appearances include Sabor in Deep Jungle, the Master Control Program & Sark in Space Paranoids, CLU & Rinzler in The Grid, the Beagle Boys in Country of the Musketeers, Julius in Traverse Town, and Davy Jones & Cutler Beckett in The Caribbean. Monstro, the whale from Pinocchio, is both a character and a location as well as a boss in Kingdom Hearts Birth by Sleep Final Mix.
Epic Mickey introduces new villains to the world of Disney, most of which are from old-style Disney films and attractions. In the first game, Mickey unwittingly creates a monster called the Shadow Blot (not to be confused with the Phantom Blot). As Mickey tries to get rid of it, Yen Sid approaches and Mickey is forced to flee, leaving some of the Blot undestroyed. Years later, the Blot has Mickey kidnapped so that his heart can be used to escape Wasteland. With Oswald's help, Mickey returns home as the Blot is defeated. The game also features an animatronic version of Captain Hook from Peter Pan as a boss.

In the second game, The Mad Doctor tries to rule in the Shadow Blot's stead. In the first game, the Mad Doctor supplied robots for the Blot. If the player choose the Hero path, The Mad Doctor turns from a robot into a toon. If the player chooses the Scrapper path, The Mad Doctor is left in the final battle room to rot. Lastly, at the end of the second game, several versions of Pete look like they're going to try to take over the Wasteland.
Several Disney Villains are present as playable characters in the video game Disney Magic Kingdoms, acting as antagonists in new storylines placed after the events of their respective films.

Alternate versions of several Disney Villains appear as playable characters in the video game Disney Mirrorverse.