Traditionally, defensive ends are in a three-point stance, with their free hand cocked back ready to "punch" an offensive lineman, or in a two-point stance like a strong safety so they can keep containment. Some defensive ends play the position due to their size; they close down their gap so the running back has no hole to run through.

A defensive end’s primary responsibilities include executing defensive assignments, sacking the quarterback, and creating loose-ball turnovers. The main goal of the defensive end on most plays is to get past the offensive lineman that is lined up opposite them.

Defensive end is one of the most difficult and demanding positions to play in football. It’s the most important player on an NFL defense vs tight ends and tackles. For this reason, they need an exceptional combination of size, strength and athleticism to be able to rush the passer, jam tight ends and drop back in coverage.