You should combine Contrave with a reduced-calorie diet and regular exercise. In fact, these lifestyle changes were part of the treatment plan used in the clinical studies of Contrave that showed more significant weight loss. Contrave may make you feel less hungry and eat less food.

A whole-food diet full of fruits and vegetables, grains, and lean proteins may be a good approach. Avoid high-fat foods with Contrave, as they can change how your body absorbs the medication.

You can take Contrave (naltrexone / bupropion) with food. But make sure to avoid taking it with high-fat meals, such as meals with eggs, avocado, or cheese. These foods can cause the medication to reach very high levels in your body, which can raise your risk for seizure.