U.S. Route 80 ( US 80) also known as the Ocean-to-Ocean Highway, the Broadway of America and the Jefferson Davis Memorial Highway was a major transcontinental highway that existed in the U.S. state of Arizona from November 11, 1926, to October 6, 1989.

U.S. 80 is one of the most historic routes traveling through Arizona. The roots of the road date back to the late 1846 and the first roads through Arizona Territory. Beginning in Yuma, the road followed the Gila River to Buckeye and Phoenix, then traveled east through the Valley to reach Florence Junction, then south to Florence.