High Street is the oldest, and one of the most historically significant, streets in Glasgow, Scotland. Originally the city's main street in medieval times, it formed a direct north–south artery between the Cathedral of St. Mungo (later Glasgow Cathedral) in the north, to Glasgow Cross and the banks of the River Clyde.

It was the cities main street in medieval times, leading from Glasgow Cathedral down past the cross and to the banks of the River Clyde - in the modern day High Street now stops at Glasgow Cross before becoming Saltmarket leading south to the Clyde. It still holds significance today as the boundary between the city centre and the east end.