The most effective broadleaf herbicide for creeping Charlie contains triclopyr, generally in combination with 2, 4-D, and Dicamba. Standard herbicides without these components don't work as well.

The best herbicide for creeping Charlie is one that contains triclopyr, which Kaminski says is “effective against broadleaf weeds like creeping Charlie, but should be used judiciously.” Don protective gear, including gardening gloves, clothing, and eyewear, and prep the herbicide.