The voice cast of Duncanville includes Poehler as both 15-year-old Duncan and his mother Annie, Ty Burrell as Duncan’s dad Jack, Riki Lindhome as Duncan’s awkward sister Kimberly, Joy Osmanski as Duncan’s adopted sister Jin, Yassir Lester as Duncan’s trend-setting friend Yangzi, Zach Cherry as Duncan’s aloof friend Wolf, Betso Sodaro as Duncan’s tomboy friend Bex, Rashida Jones as Duncan’s crush Mia, and Wiz Khalifa as Duncan’s teacher Mr. Mitch.