Queen Ramonda, Shuri, M'Baku, Okoye and the Dora Milaje fight to protect the kingdom of Wakanda from intervening world powers in the wake of King T'Challa's death. As the Wakandans strive to embrace their next chapter, the heroes must band together with the help of War Dog Nakia and Everett Ross and forge a new path for their nation.

Following the untimely death of the fierce Black Panther (2018), grieving Queen Ramonda and noble Princess Shuri struggle to find their feet in a world eager to strip Wakanda of its precious vibranium resources. But one year after the death of King T'Challa, the country faces yet another threat.

The synopsis for the film reads as the following: "Queen Ramonda (Angela Bassett), Shuri (Letitia Wright), M’Baku (Winston Duke), Okoye (Danai Gurira) and the Dora Milaje (including Florence Kasumba), fight to protect their nation from intervening world powers in the wake of King T’Challa’s death.

T'Challa, king of Wakanda, is suffering from an unspecified terminal illness which his sister Shuri believes can be cured by the "heart-shaped herb". Shuri attempts to synthetically recreate the herb after it was burned by Erik Killmonger, [a] but fails to do so before T'Challa dies.