Glyphosate is the best weed killer for honeysuckle. Add 2 tablespoons of red or blue dye formulated for herbicide use in the tank and shake it for one to two minutes to incorporate everything.Reduce the amount of glyphosate as needed if using a spray bottle.

A glyphosate product is the recommended herbicide and will lead to greater plant death, and reduced resprouting.

If you prefer using herbicides, spray the fresh-cut stumps immediately within 60 seconds following initial cutting with a 10% concentration of glyphosate (Roundup or similar) or an 8% concentration of triclopyr (Brush-Be-Gone or similar).

If you have a large stand of honeysuckle, mow or weed whack the vines as close to the ground as possible. Allow them to re-sprout, then spray the sprouts with a 5 percent solution of glyphosate. You can make the solution by mixing 4 ounces of concentrate in 1 gallon of water.

Cutting or pulling the roots by hand is not an effective way to control honeysuckle, though. If you're serious about eliminating this interloper, use a product labeled for tough brush, like Roundup® Poison Ivy Plus Tough Brush Killer products.