Cryptococcal meningitis (CM) remains an important contributor to HIV-associated deaths, accounting for an estimated 15% of overall HIV mortality globally [1]. Treatment of CM comprises three therapeutic stages: the induction, the consolidation, and the maintenance phases [2]. For induction therapy f...

Background. Cryptococcal meningoencephalitis is a lethal infection with relatively few therapeutic options. The optimal dosage of liposomal amphotericin B (LAmB) alone or in combination with flucytosine is not known. Methods. A murine model of cryptococcal meningoencephalitis was used. The fungal...

Background: The standard therapy for human immunodeficiency virus (HIV)-associated cryptococcal meningitis of amphotericin B (AmB; 0.7 mg/kg per day) plus flucytosine frequently takes >2 weeks to sterilize the cerebral spinal fluid, and acute mortality remains high. A dosage range for AmB of 0.7-1 m...