Proteins are essential to life, and understanding their structure can facilitate a mechanistic understanding of their function. Through an enormous experimental effort1-4, the structures of around 100,000 unique proteins have been determined5, but this represents a small fraction of the billions of ...

Three-dimensional protein structure is directly correlated with its function and its determination is critical to understanding biological processes and addressing human health and life science problems in general. Although new protein structures are experimentally obtained over time, there is still...

The drug discovery process involves designing compounds to selectively interact with their targets. The majority of therapeutic targets for low molecular weight (small molecule) drugs are proteins. The outstanding accuracy with which recent artificial intelligence methods compile the three-dimension...

The drug discovery process involves designing compounds to selectively interact with their targets. The majority of therapeutic targets for low molecular weight (small molecule) drugs are proteins. The outstanding accuracy with which recent artificial intelligence methods compile the three-dimension...

Proteins play a crucial role in various biological processes, and their proper fold is essential for the correct functioning of biological systems. Understanding the three-dimensional (3D1) structure of a protein holds significant importance in elucidating its function, exploring evolutionary connec...

The functions of most proteins result from their 3D structures, but determining their structures experimentally remains a challenge, despite steady advances in crystallography, NMR and single-particle cryoEM. Computationally predicting the structure of a protein from its primary sequence has long be...