Under the Fifth Periodic Review of Westminster constituencies, the Boundary Commission for England decided to increase Lancashire's representation from 15 to 16 constituencies, with the creation of Wyre and Preston North CC.

The constituency was split into two two-member divisions, for Parliamentary purposes, in 1832. The county was then represented by the North Lancashire and South Lancashire constituencies : the latter representing the hundreds of Salford and West Derby, and the former the hundreds of Amounderness, Blackburn, Leyland and Lonsdale .

It then returned one Member of Parliament (MP) to the House of Commons of the Parliament of the United Kingdom, with elections held under the first-past-the-post system. This constituency in turn was abolished when it was largely replaced by the new Lancaster and Wyre constituency for the 1997 general election .

Lancaster was a constituency of the House of Commons of the Parliament of England then of the Parliament of Great Britain from 1707 to 1800 and of the Parliament of the United Kingdom from 1801 to 1867, centred on the historic city of Lancaster in north-west England.