inspire (v.) mid-14c., enspiren, "to fill (the mind, heart, etc., with grace, etc.);" also "to prompt or induce (someone to do something)," from Old French enspirer (13c.), from Latin inspirare "blow into, breathe upon," figuratively "inspire, excite, inflame," from in- "in" (from PIE root *en "in") + spirare "to breathe" (see spirit (n.)).

This moving little word may be traced back to the Latin inspirare (“to breathe or blow into”), which itself is from the word spirare, meaning “to breathe.”

Etymology [ edit] From Middle English inspiren, enspiren, from Old French inspirer, variant of espirer, from Latin īnspīrāre, present active infinitive of īnspīrō (“inspire”), itself a loan-translation of Biblical Ancient Greek πνέω (pnéō, “breathe”), from in + spīrō (“breathe”), from Proto-Indo-European * (s)peys- (“to blow, breathe”).

Middle English enspire, from Old French inspirer, from Latin inspirare ‘breathe or blow into’ from in- ‘into’ + spirare ‘breathe’. The word was originally used of a divine or supernatural being, in the sense ‘impart a truth or idea to someone’.