The 121st season of top-tier Italian football

Napoli secured their third Serie A title and the first since 1990 with five matches to spare, following a 1–1 draw away to Udinese.

Should the first and second, or 17th and 18th-placed teams at the end of the season be tied on points, a play-off tiebreaker match would be held at a neutral site to determine the title and final team relegated respectively. The tiebreaker would not have extra time, and would instead directly go to a penalty shoot-out should the two teams be tied after 90 minutes. This was the first time play-offs were used since the 2004–05 campaign.

Lega Serie A had initially planned to run a tournament featuring Serie A teams in the United States during the 2022 FIFA World Cup, but this was later cancelled.

Juventus were deducted 15 points as punishment for capital gain violations.

The decision was overturned and Juventus were given those points back.

Following a new investigation, Juventus were docked 10 points.

UEFA released a statement confirming Juventus' violation of the financial regulations. Consequently, Juventus faced penalties including exclusion from the 2023–24 UEFA Europa Conference League.

Cagliari were relegated from the 2021–22 Serie A after six years in the top flight, Genoa were relegated to the second level after fifteen years, and Venezia were relegated after just one season in the top flight. They were replaced by 2021–22 Serie B champions Lecce, runners-up Cremonese, and play-off winners Monza. Lecce returned to the top flight after two years of absence, whilst Cremonese returned for the first time in 26 years. Monza, meanwhile, were promoted to Serie A for the first time in the club's history. They became the 67th team to play in the top flight of Italian football. This was the first season since the 2003–04 campaign without any teams from the archipelagos of Italy (teams located on the Sardinia and Sicily) in the top flight, as Cagliari were relegated.

Hellas Verona won 3–1 and remained in Serie A, while Spezia were relegated to Serie B.